FITC标记的胸苷激酶1抗体
产品名称： FITC标记的胸苷激酶1抗体
英文名称： Anti-Thymidine kinase 1/FITC
产品编号： HZ-7372R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Thymidine kinase 1/FITC Conjugated antibody
FITC标记的胸苷激酶1抗体
| 英文名称 | Anti-Thymidine kinase 1/FITC |
| 中文名称 | FITC标记的胸苷激酶1抗体 |
| 别 名 | cytosolic; KITH_HUMAN; Thymidine kinase 1; Thymidine kinase 1 soluble; Thymidine kinase 1 soluble isoform; Thymidine kinase; Thymidine kinase cytosolic; TK 1; TK 2; TK1; Tk1a; Tk1b; TK2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 激酶和磷酸酶 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 25kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Thymidine kinase 1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Thymidine Kinase (TK1) is a highly conserved phosphotransferase that is present in most living cells. Thymidine Kinase catalyzes the phosphorylation reaction: deoxythymidine + ATP = deoxythymidine 5'-phosphate + ADP; it is thus involved in the reaction chain to introduce deoxythymidine into the DNA. Thymidine kinase is required for the action of many antiviral drugs, such as azidothymidine (AZT), and is is also used to select hybridoma cell lines in the production of monoclonal antibodies. Thymidine Kinase has many clinical applications as it is only present in anticipation of cell division. Because of this, Thymidine Kinase can be used as a proliferation marker in the diagnosis, treatment, and follow-up of malignant diseases, especially hematological malignancies. Thymidine Kinase may be observed as a monomer, dimer, trimer or tetramer. Subunit: Homotetramer. Subcellular Location: Cytoplasm. Post-translational modifications: Phosphorylated on Ser-13 in mitosis. Similarity: Belongs to the thymidine kinase family. Database links: Entrez Gene: 7083 Human Omim: 188300 Human SwissProt: P04183 Human Unigene: 515122 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Thymidine Kinase（TK1）是一种高度保守的磷酸转移酶，存在于大多数活细胞中。Thymidine Kinase catalyzes磷酸化反应：脱氧胸苷+ATP＝脱氧胸苷5’-磷酸+ ADP；因此参与反应链将脱氧胸苷引入DNA中。Thymidine kinase需要许多抗病毒药物的作用，如叠氮胸苷（AZT），而Is也用于选择杂交瘤细胞系中产生单克隆抗体。Thymidine Kinase有许多临床应用，因为它只存在于细胞分裂的预期中。因此，Thymidine Kinase可作为恶性疾病尤其是血液系统恶性肿瘤的诊断、治疗和随访的增殖标志物。Thymidine Kinase可被观察为单体、二聚体、三聚体或四聚体。