Rabbit Anti-DLEC1/FITC Conjugated antibody
|别 名||Deleted in lung and esophageal cancer 1; Deleted in lung and esophageal cancer 1 transcript varient 2; Deleted in lung and esophageal cancer protein 1; Deleted in lung cancer protein 1; DLC 1; Dlc-1; DLC1; Dlec1; DLEC1_HUMAN; F56.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||肿瘤 细胞生物 表观遗传学|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||196kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human DLEC1|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
This gene contains 37 exons, spans approximately 59-kb, and is located in the 3p22-p21.3 chromosomal segment that is commonly deleted in various carcinomas. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins. Aberrant transcription of this gene may be involved in carcinogenesis of the lung, esophagus, and kidney. [provided by RefSeq, Jul 2008]
May act as a tumor suppressor by inhibiting cell proliferation.
Expressed in all tissues examined. Expression is highest in prostate and testis.
Note=DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of different cancers, including esophageal, renal and lung cancers.
Entrez Gene: 9940 Human
Omim: 604050 Human
SwissProt: Q9Y238 Human
Unigene: 714499 Human
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
该基因包含37个外显子，跨度约59-kb，位于各种癌症中通常缺失的3p22-p21.3染色体段。已经观察到一些选择性剪接的转录本，它们含有中断的编码区，并且可能编码非功能性蛋白质。该基因的异常转录可能参与肺癌、食道和肾脏的癌变过程。[ RefSeq，JUL 2008 ]