FITC标记的DIMT1L蛋白抗体
产品名称： FITC标记的DIMT1L蛋白抗体
英文名称： Anti-DIMT1L/FITC
产品编号： HZ-14331R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
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Rabbit Anti-DIMT1L/FITC Conjugated antibody
FITC标记的DIMT1L蛋白抗体
| 英文名称 | Anti-DIMT1L/FITC |
| 中文名称 | FITC标记的DIMT1L蛋白抗体 |
| 别 名 | 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase; 18S rRNA dimethylase; DIM1 dimethyladenosine transferase 1 homolog; DIM1 dimethyladenosine transferase 1 like; DIM1 dimethyladenosine transferase 1-like; Dimethyladenosine transferase; DIMT1; DIM1_HUMAN; DIMT1L; HSA9761; HUSSY5; N''-adenosyl(rRNA) dimethyltransferase; Probable 18S rRNA dimethylase; Probable dimethyladenosine transferase; S adenosylmethionine 6 N',N' adenosyl(rRNA) dimethyltransferase; S-adenosylmethionine-6-N''. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 35kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DIMT1L |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: DIMT1 is a 313 amino acid protein that belongs to the rRNA adenine N(6)-methyltransferase family. Localized to the nucleolus, DIMT1 functions to dimethylate adjacent adenosines on the conserved hairpin loop of 18S rRNA in the 40S particle. The gene encoding DIMT1 maps to chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Chromosome 5 is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5-associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. Function: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Subcellular Location: Nucleus > nucleolus. Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. Database links: Entrez Gene: 27292 Human GenBank: NM_014473 Human SwissProt: Q9UNQ2 Human Unigene: 726092 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
DIMT1是属于rRNA腺嘌呤N（6）甲基转移酶家族的313个氨基酸。DIMT1定位于核仁，在40S颗粒中18S rRNA的保守发夹环上甲基化相邻的腺苷。编码DIMT1的基因映射到5号染色体，其包含1亿8100万个碱基对，并包含人类基因组的近6%。5号染色体通过ERCC8基因与Cockayne综合征相关，家族性腺瘤性息肉病通过APC抑癌基因与腺瘤性息肉病相关。Treacher Collins综合征也是5号染色体相关的，是由TCOF1基因内的插入或缺失引起的。5号染色体p臂缺失导致Cri du chat综合征，而q臂或5号染色体缺失在治疗相关的急性髓细胞白血病和骨髓增生异常综合征中很常见。