Rabbit Anti-DNAJB14/FITC Conjugated antibody
|别 名||5730496F10Rik; DJB14_HUMAN; DnaJ (Hsp40) homolog, subfamily B, member 14; DnaJ homolog subfamily B member 14; dnajb14; EGNR9427; FLJ14281; MGC22187; PRO34683; UNQ9427/PRO34683.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|交叉反应||Human, Mouse, Rat, Rabbit,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||42kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human DNAJB14|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
The DnaJ family, one of the largest of all the chaperone families, has evolved with diverse cellular localization and functions. The presence of a J domain defines a protein as a member of the DnaJ family. DnaJ heat-shock induced proteins are derived from the bacterium Escherichia coli and are under the control of the htpR regulatory protein. DnaJ proteins play a critical role in the HSP 70 chaperone machine by interacting with HSP 70 to stimulate ATP hydrolysis. Members of this family contain cysteine-rich regions that are composed of zinc fingers that form a peptide-binding domain responsible for chaperone function. DnaJ family members are important mediators of proteolysis and are involved in the regulation of protein degradation, exocytosis and endocytosis. DnaJB14 (DnaJ (Hsp40) homolog, subfamily B, member 14) is a 379 amino acid single-pass membrane protein containing one J domain and is thought to act as a co-chaperone. DnaJB14 exists as two alternatively spliced isoforms.
May act as a co-chaperone.
Contains 1 J domain.
Entrez Gene: 79982 Human
SwissProt: Q8TBM8 Human
Unigene: 577426 Human
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
DnaJ家族是所有伴侣分子家族中最大的家族之一，其进化具有不同的细胞定位和功能。J域的存在定义了作为DnaJ家族成员的蛋白质。DNJ热休克诱导蛋白来源于细菌大肠杆菌，并在HTPR调节蛋白的控制下。DNJ蛋白在HSP 70伴侣机器中与HSP 70相互作用以刺激ATP水解起关键作用。该家族的成员含有富含锌的区域，其由锌指组成，其形成负责伴侣功能的肽结合域。DnaJ家族成员是蛋白质分解的重要介质，参与蛋白质降解、胞吐和胞吞的调节。DNJB14（DnaJ（HSP40）同源物，亚家族B，成员14）是含有一个J结构域的379氨基酸单程膜蛋白，被认为是共同伴侣。DNaJB14以两种交替剪接异构体存在。