Rabbit Anti-Brachyury/FITC Conjugated antibody
|别 名||BRAC_HUMAN; Brachyury homolog; Brachyury protein; Bry; MGC104817; Protein T; T; T brachyury homolog; T Protein; T, brachyury homolog (mouse); TFT; Transcription factor T。|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||心血管 发育生物学 干细胞 转录调节因子|
|交叉反应||Human, Mouse, Rat,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||48kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human Brachyury|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.
Neural tube defects (NTD) [MIM:182940]: Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Chordoma (CHDM) [MIM:215400]: Rare, clinically malignant tumors derived from notochordal remnants. They occur along the length of the spinal axis, predominantly in the sphenooccipital, vertebral and sacrococcygeal regions. They are characterized by slow growth, local destruction of bone, extension into adjacent soft tissues and rarely, distant metastatic spread. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication.
Contains 1 T-box DNA-binding domain.
Entrez Gene: 6862 Human
Entrez Gene: 20997 Mouse
Omim: 601397 Human
SwissProt: O15178 Human
SwissProt: P20293 Mouse
Unigene: 389457 Human
Unigene: 913 Mouse
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
由该基因编码的蛋白质是胚胎细胞核转录因子，结合特定的DNA元素，回文T位点。它通过它的N-末端，称为T-box的区域结合，并影响中胚层形成和分化所需的基因的转录。该蛋白定位于脊索来源的细胞。发现了两个编码不同亚型的转录变体。[ RefSeq，JUL 2012 ]