Rabbit Anti-DNAJC21/FITC Conjugated antibody
|别 名||DJC21_HUMAN; DnaJ homolog subfamily A member 5; DnaJ homolog subfamily C member 21; DNAJA5; dnajc21; GS3; JJJ1; Protein GS3.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||细胞生物 神经生物学 信号转导 转运蛋白|
|交叉反应||Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||62kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human DNAJC21|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
With the presence of the J domain defining a protein as a member, the DnaJ family has evolved with diverse cellular localization and functions and is one of the largest chaperone families. DnaJ heat-shock-induced proteins are derived from the bacterium Escherichia coli and are controlled by the htpR regulatory protein. DnaJ proteins play a critical role in the HSP 70 chaperone machine by interacting with HSP 70 to stimulate ATP hydrolysis. Members of this family contain cysteine-rich regions composed of zinc fingers that form a peptide-binding domain responsible for chaperone function. DnaJ proteins are important mediators of proteolysis and are involved in the regulation of protein degradation, exocytosis and endocytosis. DNAJC21 (DnaJ homolog subfamily C member 21), also known as DNAJA5 or JJJ1, is a 531 amino acid protein that contains two C2H2-type zinc fingers and one J domain. Expressed in placenta, pancreas, kidney and brain, DNAJC21 may be a co-chaperone for HSP 70.
May act as a co-chaperone for HSP70.
Brain, placenta, kidney and pancreas.
Contains 2 C2H2-type zinc fingers.
Contains 1 J domain.
Entrez Gene: 134218 Human
SwissProt: Q5F1R6 Human
Unigene: 131887 Human
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
随着J结构域的存在，将蛋白质定义为成员，DnaJ家族已经进化为具有多种细胞定位和功能的家族，并且是最大的伴侣家族之一。DnaJ热休克诱导蛋白来源于大肠杆菌，由htpR调节蛋白控制。DNJ蛋白在HSP 70伴侣机器中与HSP 70相互作用以刺激ATP水解起关键作用。这个家族的成员含有富含半胱氨酸的区域，这些区域由锌指组成，锌指形成负责伴侣功能的肽结合结构域。DnaJ蛋白是蛋白水解的重要介质，参与蛋白质降解、胞吐和胞内吞的调节。DNAJC21(DnaJ同源亚家族C成员21)又称DNAJA5或JJJ1，是含有两个C2H2型锌指和一个J结构域的531个氨基酸蛋白。DNJC21在胎盘、胰腺、肾脏和脑中表达，可作为HSP 70的伴侣伴侣。