Rabbit Anti-DNAJC2/FITC Conjugated antibody
|别 名||Zuotin-1; AU020218; DnaJ (Hsp40) homolog subfamily C member 2; DnaJ homolog subfamily C member 2; Dnajc2; DNJC2_HUMAN; M phase phosphoprotein 11; M-phase phosphoprotein 11; MGC105894; MIDA1; MPHOSPH11; MPP11; OTTMUSP00000031226; ZRF1; Zrf2; ZUO1; Zuotin related factor 1; Zuotin related factor 2; Zuotin-related factor 1.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||肿瘤 细胞生物 信号转导|
|交叉反应||Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, Sheep,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||72kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human DNAJC2|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008]
Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.
Nucleus. Cytoplasm > cytosol.
Phosphorylated in M (mitotic) phase.
Contains 1 J domain.
Contains 2 SANT domains.
Entrez Gene: 27000 Human
Entrez Gene: 507897 Cow
Entrez Gene: 22791 Mouse
Entrez Gene: 116456 Rat
Omim: 605502 Human
SwissProt: Q1RMH9 Cow
SwissProt: Q99543 Human
SwissProt: P54103 Mouse
SwissProt: Q7TQ20 Rat
Unigene: 558476 Human
Unigene: 266312 Mouse
Unigene: 11908 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
该基因是M期***蛋白（MPP）家族的成员。该基因编码具有J结构域和Myb DNA结合结构域的***酸蛋白，该结构域定位于细胞核和细胞溶胶。该蛋白质能够形成与核糖体结合的异二聚复合物，当新生多肽链离开核糖体时作为分子伴侣。该蛋白被鉴定为白血病相关抗原，该基因在白血病细胞中表达上调。此外，涉及该基因的染色体畸变与原发性头颈部鳞状细胞肿瘤有关。这个基因在第6号染色体上有假基因。还描述了编码不同蛋白质亚型的剪接变异体。[ RefSeq，JUL 2008 ]