FITC标记的DNAJC2蛋白抗体上海沪震实业有限公司

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产品名称: FITC标记的DNAJC2蛋白抗体
英文名称: Anti-DNAJC2/FITC
抗体货号: HZ-14386R-FITC
产品规格: 100ul
级    别: , , 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/10/12 10:10:00
详细资料:  实验方法技术资料
浏览人数:9
诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-DNAJC2/FITC Conjugated antibody

FITC标记的DNAJC2蛋白抗体

 

英文名称 Anti-DNAJC2/FITC
中文名称 FITC标记的DNAJC2蛋白抗体
别    名 Zuotin-1; AU020218; DnaJ (Hsp40) homolog subfamily C member 2; DnaJ homolog subfamily C member 2; Dnajc2; DNJC2_HUMAN; M phase phosphoprotein 11; M-phase phosphoprotein 11; MGC105894; MIDA1; MPHOSPH11; MPP11; OTTMUSP00000031226; ZRF1; Zrf2; ZUO1; Zuotin related factor 1; Zuotin related factor 2; Zuotin-related factor 1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 72kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DNAJC2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008]

Function:
Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.

Subcellular Location:
Nucleus. Cytoplasm > cytosol.

Tissue Specificity:
Widely expressed.

Post-translational modifications:
Phosphorylated in M (mitotic) phase.

Similarity:
Contains 1 J domain.
Contains 2 SANT domains.

Database links:

Entrez Gene: 27000 Human

Entrez Gene: 507897 Cow

Entrez Gene: 22791 Mouse

Entrez Gene: 116456 Rat

Omim: 605502 Human

SwissProt: Q1RMH9 Cow

SwissProt: Q99543 Human

SwissProt: P54103 Mouse

SwissProt: Q7TQ20 Rat

Unigene: 558476 Human

Unigene: 266312 Mouse

Unigene: 11908 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

该基因是M期***蛋白(MPP)家族的成员。该基因编码具有J结构域和Myb DNA结合结构域的***酸蛋白,该结构域定位于细胞核和细胞溶胶。该蛋白质能够形成与核糖体结合的异二聚复合物,当新生多肽链离开核糖体时作为分子伴侣。该蛋白被鉴定为白血病相关抗原,该基因在白血病细胞中表达上调。此外,涉及该基因的染色体畸变与原发性头颈部鳞状细胞肿瘤有关。这个基因在第6号染色体上有假基因。还描述了编码不同蛋白质亚型的剪接变异体。[ RefSeq,JUL 2008 ]

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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