Anti-Annexin A2抗体-抗体-抗体-生物在线
Anti-Annexin A2抗体

Anti-Annexin A2抗体

商家询价

产品名称: Anti-Annexin A2抗体

英文名称: Annexin A2

产品编号: YB--0576R

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

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 Anti-Annexin A2抗体

产品编号 YB-0576R
英文名称 Annexin A2
中文名称 膜粘连蛋白 Ⅱ抗体
别    名 Annexin A2; ANX 2; ANX2; ANX2L4; ANXA2; arylsulfatase B; CAL1H; Calpactin I heavy chain; calpactin I heavy polypeptide (p36); chromobindin 8; LIP2; Lipocortin II; LPC2; LPC2D; P36; P36 protein; PAP-IV; placental anticoagulant protein IV; Protein I; ANXA2_HUMAN; Annexin II; Annexin-2; Calpactin-1 heavy chain; Chromobindin-8; Placental anticoagulant protein IV.  
Specific References  (1)     |     bs-0576R has been referenced in 1 publications.
[IF=2.84] Geng, Xiaofang, et al. "Differential proteome analysis of the cell differentiation regulated by BCC, CRH, CXCR4, GnRH, GPCR, IL1 signaling pathways in Chinese fire-bellied newt limb regeneration." Differentiation (2014).  WB ;  
PubMed:25465723
 
规格价格 50ul/780元 购买    100ul/1380元 购买    200ul/2200元 购买    大包装/询价
说 明 书 50ul  100ul  200ul
研究领域 肿瘤  心血管  细胞生物  信号转导  细胞凋亡  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Sheep, 
产品应用 WB=1:500-2000 ELISA=1:500-1000  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 36kDa
细胞定位 细胞浆 细胞膜 细胞外基质 分泌型蛋白 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Annexin II:256-339/339 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.

Subunit:
Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF. Interacts with human cytomegalovirus (HCMV). Interacts with COCH.

Subcellular Location:
Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.

Post-translational modifications:
Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. 
ISGylated.

Similarity:
Belongs to the annexin family.
Contains 4 annexin repeats.

SWISS:
P07355

Gene ID:
302

Database links:

Entrez Gene: 302 Human

Entrez Gene: 12306 Mouse

Entrez Gene: 56611 Rat

Omim: 151740 Human

SwissProt: P07355 Human

SwissProt: P07356 Mouse

SwissProt: Q07936 Rat

Unigene: 511605 Human

Unigene: 238343 Mouse

Unigene: 90546 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

信号传导(Signaling Intermediates)
Annexin 2是新近发现的纤维蛋白溶解酶原(PLG)和组织型纤溶蛋白溶解酶原激活物(t-PA)的共受体,是Ca2+介导具有高亲和力的磷脂结合蛋白.其介导血管内外纤维蛋白溶解,对保持机体内环境稳定具有重要作用.
依赖性膜磷脂结合蛋白Annexin II调控异常及有害因子的作用,可导致血栓性疾病和动脉硬化症
钙依赖性膜磷脂结合蛋白膜粘连蛋白2异常高表达所引起纤溶亢进,是白血病等恶性肿瘤出血合并症重要机制之一.钙依赖性磷脂结合蛋白对其干预和调控可能为治疗上述病症提供新思路,为临床治疗开辟新途径.
产品图片
Cell: U937.
Concentration: 1:50.
Incubation: 40 minutes, room temperature. 
Host/Blank: U937 cells. 
Flow cytometric analysis of Rabbit Anti-Annexin A2/FITC Conjugated antibody (bs-0576R-FITC) (green) compared with control in the absence of primary antibody (blue) followed by U937 cells.