Anti-ELMOD2抗体上海钰博生物科技有限公司

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产品名称: Anti-ELMOD2抗体
英文名称: ELMOD2
抗体货号: YB--14568R
产品规格: 20ul/50ul/100ul/200ul
级    别: 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 1380元
抗原: KLH conjugated synthetic peptide derived from human ELMOD2:151-250/293
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2018/12/5 13:47:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-ELMOD2抗体

产品编号 YB-14568R
英文名称 ELMOD2
中文名称 ELMOD2蛋白抗体
别    名 9830169G11Rik; ELMD2_HUMAN; ELMO domain containing 2; ELMO domain containing protein 2; ELMO domain-containing protein 2; ELMO/CED 12 domain containing 2; ELMOD2; MGC10084.  
规格价格 100ul/1380元 购买    200ul/2200元 购买    大包装/询价
说 明 书 100ul  200ul
研究领域 细胞生物  信号转导  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 35kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ELMOD2:151-250/293 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
ELMOD2 is a 293 amino acid protein that is one of six human proteins that contain an ELMO domain. ELMOD2 is thought to interact with DOCK1 through a SH3-binding site, which enhances the guanine nucleotide exchange factor (GEF) activity of DOCK1. Therefore, ELMOD2 may also be part of a complex with DOCK1 and Rac1 that is required to activate Rac Rho small GTPases. Evidence of decreased ELMOD2 expression in lung of individuals with familial idiopathic pulmonary fibrosis (IPF) suggests that defects in the gene encoding ELMOD2 may be linked to susceptibility for familial IPF.

Function:
Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses.

Tissue Specificity:
Alveolar cells (morphologically type II cells) and alveolar macrophages (at protein level). Expressed in brain, colon, heart, kidney, liver, lung, muscle, placenta, small intestine, spleen, stomach and testis. In lung it is expressed in alveolar macrophages and alveolar walls.

Similarity:
Contains 1 ELMO domain.

SWISS:
Q8IZ81

Gene ID:
255520

Database links:

Entrez Gene: 255520 Human

Entrez Gene: 244548 Mouse

Entrez Gene: 688581 Rat

Omim: 610196 Human

SwissProt: Q8IZ81 Human

SwissProt: Q8BGF6 Mouse

Unigene: 450105 Human

Unigene: 38762 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
 
产品图片
Sample: 
oocyte (Mouse) CellLysate at 40 ug
Primary: Anti-ELMOD2 (bs-14568R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 35 kD
Observed band size: 35 kD

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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