Rabbit Anti-IL-1 Beta/FITC Conjugated antibody
|别 名||Catabolin; H1; IL-1β; Hematopoietin 1; IFN beta inducing factor; IL 1; IL 1 beta; IL 1B; IL1B; IL1F2; Interleukin 1 beta; Interleukin 1 beta precursor; LAF; OAF; Osteoclast activating factor; Preinterleukin beta; Pro interleukin 1 beta; IL1B_HUMAN; Interleukin-1 beta; IL-1 beta.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||细胞生物 免疫学 糖蛋白|
|交叉反应||Human, Mouse, Rat, Bee,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||17kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human IL-1 Beta|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008].
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
Belongs to the IL-1 family.
Entrez Gene: 3553 Human
Entrez Gene: 16176 Mouse
Entrez Gene: 24494 Rat
Omim: 147720 Human
SwissProt: P01584 Human
SwissProt: P10749 Mouse
SwissProt: Q63264 Rat
Unigene: 126256 Human
Unigene: 222830 Mouse
Unigene: 9869 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
由该基因编码的蛋白质是白细胞介素1细胞因子家族的成员。这种细胞因子是由活化的巨噬细胞产生的一种前体蛋白，它被caspase 1(CASP1/ICE)蛋白水解为它的活性形式。该细胞因子是炎症反应的重要介质，参与多种细胞活动，包括细胞增殖、分化和凋亡。这种细胞因子在中枢神经系统（CNS）中诱导环氧合酶-2（PTGS2/COX2）参与炎症性疼痛超敏反应。该基因和八个其他白细胞介素1家族基因在2号染色体上形成细胞因子基因簇。[ RefSeq，JUL 2008 ]提供。