Anti-EXOSC4抗体上海钰博生物科技有限公司

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产品名称: Anti-EXOSC4抗体
英文名称: EXOSC4
抗体货号: YB--14667R
产品规格: 20ul/50ul/100ul/200ul
级    别: 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 1380元
抗原: KLH conjugated synthetic peptide derived from human EXOSC4:51-150/245
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2018/12/5 14:07:00
详细资料:  实验方法技术资料
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诚信指数:1476点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-EXOSC4抗体

产品编号 YB-14667R
英文名称 EXOSC4
中文名称 EXOSC4蛋白抗体
别    名 EXOSC 4; Exosome complex component RRP41; Exosome complex exonuclease RRP41; Exosome component 4; Exosome component Rrp41; FLJ20591; hRrp41p; p12A; EXOS4_HUMAN; Ribosomal RNA processing protein 41; RRP 41; RRP41; RRP41A; Rrp41p; SKI 6; SKI6; Ski6p.  
规格价格 100ul/1380元 购买    200ul/2200元 购买    大包装/询价
说 明 书 100ul  200ul
研究领域 细胞生物  转运蛋白  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 
产品应用 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 26kDa
细胞定位 细胞核 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EXOSC4:51-150/245 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
The exosome is a multisubunit complex composed of several highly conserved subunits, some of which are 3’ to 5’ exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich (ARE) elements in their untranslated 3’ region. EXOSC4 (exosome component 4), also known as SKI6, RRP41 or p12A, is a 245 amino acid protein that localizes to both the nucleus and the cytoplasm and shares 96% sequence identity with its mouse counterpart. Functioning as a component of the exosome complex, EXOSC4 exhibits 3'-5' exonuclease activity and is required for the 3'-processing of 7S pre-RNA to mature 5.8S rRNA. The gene encoding EXOSC4 maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.

Function:
EXOSC4 belongs to the RNase PH family. It is a component of the exosome 3'->5' exoribonuclease complex and is required for the 3' processing of the 7S pre-RNA to the mature 5.8S rRNA. It has a 3'-5' exonuclease activity.

Subunit:
Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Interacts with DDX60.

Subcellular Location:
Cytoplasm. Nucleus, nucleolus.

Similarity:
Belongs to the RNase PH family.

SWISS:
Q9NPD3

Gene ID:
54512

Database links:

Entrez Gene: 54512 Human

Entrez Gene: 618292 Cow

Entrez Gene: 109075 Mouse

Entrez Gene: 300045 Rat

Omim: 606491 Human

SwissProt: Q7YRA3 Cow

SwissProt: Q9NPD3 Human

SwissProt: Q921I9 Mouse

Unigene: 632041 Human

Unigene: 322752 Mouse

Unigene: 28481 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
 
产品图片
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (EXOSC4) Polyclonal Antibody, Unconjugated (bs-14667R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

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