FITC标记的同源转录因子DLX5抗体上海沪震实业有限公司

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产品名称: FITC标记的同源转录因子DLX5抗体
英文名称: Anti-Dlx5/FITC
抗体货号: HZ-20456R-FITC
产品规格: 100ul
级    别: , , 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/12/5 14:09:00
详细资料:  实验方法技术资料
浏览人数:5
诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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上海·中国-上海
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产品详细描述

 Rabbit Anti-Dlx5/FITC Conjugated antibody

FITC标记的同源转录因子DLX5抗体

 

英文名称 Anti-Dlx5/FITC
中文名称 FITC标记的同源转录因子DLX5抗体
别    名 Distal less homeo box 5; Distal less homeobox 5; Dlx 5; Homeo box protein DLX 5; Homeo box protein DLX5; Homeobox protein DLX 5; Homeobox protein DLX5; DLX5_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  神经生物学  信号转导  干细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应  
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 31kDa
性    状 Lyophilized or Liquid
浓    度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Dlx5
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Dlx5 (distal-less homeobox 5) gene is a member of a homeobox gene family similiar to the Drosophila distal-less gene. The encoded Dlx5 protein is localized to the nucleus where it functions as a transcriptional regulator during neural development. In the developing CNS, Dlx5 is one of the earliest known markers before the formation of an overt neural plate. During late gastrulation Dlx5 (gene) expression becomes localized to the anterior neural ridge, which defines the rostral boundary of the neural plate, and also extends caudolaterally, marking the region of the presumptive neural crest. Subsequently, Dlx5 is expressed in tissues (olfactory epithelium, ventral cephalic epithelium) that are believed to derive from the anterior neural ridge.

Function:
Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding.

Subunit:
Interacts with XRCC6 (Ku70).

Subcellular Location:
Nuclear.

Post-translational modifications:
Phosphorylated. Phosphorylation of Ser-34 and Ser-217 by MAPK14 enhances its transcriptional activity. Phosphorylation by CaMK2 increases its protein stability (By similarity).

DISEASE:
Defects in DLX5 are the cause of split-hand/foot malformation type 1, with sensorineural hearing loss (SHFM1D) [MIM:220600]. A disease characterized by the association of split-hand/foot malformation with deafness. Split-hand/foot malformation is a limb malformation involving the central rays of he autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting.

Similarity:
Belongs to the distal-less homeobox family.
Contains 1 homeobox DNA-binding domain.

Database links:
Entrez Gene: 1749 Human
Entrez Gene: 13395 Mouse
Entrez Gene: 25431 Rat
Omim: 600028 Human
SwissProt: P56178 Human
SwissProt: P70396 Mouse
SwissProt: P50575 Rat


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

Dlx5(远端非同源盒5)基因是果蝇远端非同源盒基因家族的成员。编码的Dlx5蛋白定位于细胞核,在神经发育过程中它起着转录调节作用。在发展中的中枢神经系统中,Dlx5是显性神经板形成之前已知的最早的标志物之一。在晚期原肠形成过程中,Dlx5(基因)的表达变得局限于前神经脊,前神经脊限定了神经板的嘴侧边界,并且还向尾侧延伸,标记了推测神经嵴的区域。随后,Dlx5在被认为来源于前神经脊的组织(嗅上皮、腹侧头皮上皮)中表达。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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