FITC标记的线粒体内膜转位酶8B上海沪震实业有限公司

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产品名称: FITC标记的线粒体内膜转位酶8B
英文名称: Anti-TIMM8B/FITC
抗体货号: HZ-23056R-FITC
产品规格: 100ul
级    别: , , 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/12/5 14:43:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-TIMM8B/FITC Conjugated antibody

FITC标记的线粒体内膜转位酶8B

 

英文名称 Anti-TIMM8B/FITC
中文名称 FITC标记的线粒体内膜转位酶8B
别    名 DDP2; Deafness dystonia protein 2; FLJ21744; MGC102866; MGC117373; Mitochondrial import inner membrane translocase subunit Tim8 B; Small zinc finger like protein DDP2; TIM8B; ranslocase of inner mitochondrial membrane 8 homolog B (yeast); Translocase of inner mitochondrial membrane 8 homolog b;   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  线粒体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 9kDa
性    状 Lyophilized or Liquid
浓    度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TIMM8B
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.[provided by RefSeq, Aug 2009]

Function:
Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).

Subunit:
Heterohexamer; possibly composed of 3 copies of TIMM8B and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22 (By similarity).

Subcellular Location:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.

Tissue Specificity:
Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.

Similarity:
Belongs to the small Tim family.

Database links:
Entrez Gene: 26521 Human
Entrez Gene: 30057 Mouse
Entrez Gene: 64372 Rat
Omim: 606659 Human
SwissProt: Q9Y5J9 Human
SwissProt: P62077 Mouse
SwissProt: P62078 Rat


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

该基因编码一个与酵母Tim线粒体导入蛋白相似的蛋白家族成员。该基因由核基因编码,并被转运到线粒体的膜间空间。当形成复合物时,这些蛋白质引导跨膜蛋白穿过线粒体膜间空间,然后将它们加入线粒体内膜。该基因与琥珀酸脱氢酶D亚基(SDHD)相邻,其中在遗传性副神经节瘤家族的受影响成员中发现了突变。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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