FITC标记的有丝分裂原诱导基因6抗体上海沪震实业有限公司

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产品名称: FITC标记的有丝分裂原诱导基因6抗体
英文名称: Anti-MIG6/FITC
抗体货号: HZ-20291R-FITC
产品规格: 100ul
级    别: , , 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/12/5 14:46:00
详细资料:  实验方法技术资料
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诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-MIG6/FITC Conjugated antibody

FITC标记的有丝分裂原诱导基因6抗体

 

英文名称 Anti-MIG6/FITC
中文名称 FITC标记的有丝分裂原诱导基因6抗体
别    名 ERBB receptor feedback inhibitor 1; GENE 33; MIG6; mitogen inducible gene 6; mitogen inducible gene 6 protein; RALT; receptor-associated late transducer; ERRFI_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  心血管  免疫学  信号转导  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 51kDa
性    状 Lyophilized or Liquid
浓    度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human MIG6
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
ERRFI1 belongs to a class of mammalian regulators of tyrosine kinase signalling, whose expression is trascriptionally controlled by receptor activation. A number of features reveal this protein as a canidate for being a signal transducing protein; proline rich sequences, consensus sequences for phosphorylation of ERK1 and ERK2, a potential binding site for 14-3-3 proteins and other potential sites for phosphorylation by protein kinase C, A and Casein kinase II.

Function:
Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development 

Subunit:
interacts with ERBB2. Interacts with EGFR. 

Subcellular Location:
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes.

Similarity:
Belongs to the MIG6 family. 

Database links:

Entrez Gene: 54206 Human

Omim: 608069 Human

SwissProt: Q9UJM3 Human

Unigene: 605445 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

ERRFI1是一类哺乳动物酪氨酸激酶信号转导的调节因子,其表达受受体激活控制。许多特征显示该蛋白是作为信号转导蛋白的犬酸盐;富含脯氨酸的序列,ERK1和ERK2***酸化的一致序列,14-3-3蛋白的潜在结合位点,以及蛋白激酶C、A和Case***酸化的其他潜在位点。在激酶II中。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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