FITC标记的微管相关蛋白轻链3C抗体
产品名称： FITC标记的微管相关蛋白轻链3C抗体
英文名称： Anti-LC3C/FITC
产品编号： HZ-20416R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-LC3C/FITC Conjugated antibody
FITC标记的微管相关蛋白轻链3C抗体
| 英文名称 | Anti-LC3C/FITC |
| 中文名称 | FITC标记的微管相关蛋白轻链3C抗体 |
| 别 名 | LC3 like protein 2; MAP1 light chain 3 like protein 3; Microtubule-associated proteins 1A/1B light chain 3C; Autophagy-related protein LC3 C; Autophagy-related ubiquitin-like modifier LC3 C; MAP1 light chain 3-like protein 3; MAP1A/MAP1B light chain 3 C; MAP1A/MAP1B LC3 C; Microtubule-associated protein 1 light chain 3 gamma; MAP1LC3C; MLP3C_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 信号转导 细胞骨架 细胞自噬 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, |
| 产品应用 | Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 16kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LC3C |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. LC3, a ubiquitin-like modifier protein, is the human homolog of yeast Apg8 and is involved in the formation of autophagosomal vacuoles, called autophagosomes. There are three isoforms of human LC3 (named MAP1LC3A, MAP1LC3B, and MAP1LC3C), which exhibit different tissue distributions. A disruption to the autophagic process is now associated with the progression of several cancers, neurodegenerative disorders and cardiac pathologies, where LC3 is widely employed as a marker for autophagy. Function: Probably involved in formation of autophagosomal vacuoles (autophagosomes). Subunit: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Subcellular Location: Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Tissue Specificity: Most abundant in placenta, lung and ovary. Similarity: Belongs to the MAP1 LC3 family. Database links: Entrez Gene: 440738 Human Omim: 609605 Human SwissProt: Q9BXW4 Human Unigene: 534971 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
细胞内稳态的主要贡献是细胞在细胞成分的形成和降解/去除之间取得平衡的能力。这种内部细胞转变的过程被称为自噬（自食），并且通过大约16个相互作用的蛋白质在人体内的通路来促进。LC3是一种泛素样修饰蛋白，是酵母Apg8的人类同源物，参与自噬体空泡的形成，称为自噬体。人LC3有三种亚型（MAP1LC3A、MAP1LC3B和MAP1LC3C），它们具有不同的组织分布。自噬过程的破坏现在与一些癌症、神经退行性疾病和心脏病理的进展相关，其中LC3被广泛用作自噬的标志。