FITC标记的蛋白酪氨酸磷酸酶PTPσ抗体
产品名称： FITC标记的蛋白酪氨酸磷酸酶PTPσ抗体
英文名称： Anti-PTPRS/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PTPRS/FITC Conjugated antibody
FITC标记的蛋白酪氨酸磷酸酶PTPσ抗体
| 英文名称 | Anti-PTPRS/FITC |
| 中文名称 | FITC标记的蛋白酪氨酸磷酸酶PTPσ抗体 |
| 别 名 | Protein tyrosine phosphatase PTPsigma; Protein tyrosine phosphatase receptor type S; Protein tyrosine phosphatase receptor type sigma; Ptprs; PTPRS_HUMAN; PTPSIGMA; R PTP sigma; R-PTP-S; R-PTP-sigma; Receptor-type tyrosine-protein phosphatase S; Receptor-type tyrosine-protein phosphatase sigma. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 214kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PTPRS |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Protein tyrosine phosphatases, or PTPs, are type I transmembrane proteins, membrane associated proteins or proteins localized in nuclei. Examples of transmembrane PTPs are LAR, PTP alpha, PTP beta, PTP gamma, PTP delta, PTP epsilon, PTP zeta, PTP thet, PTP upsilon and PTPs. Transmembrane PTPsigma play diverse roles during development and in adult tissues. Immunodepletion studies have suggested LAR to be a regulator of insulin receptor phosphorylation. PTP alpha activity is increased twofold in response to phorbol ester stimulation, resulting in serine phosphorylation either directly or indirectly by members of the PKC family. Overexpression of v-H-Ras and Neu, but not Myc or Int2, in mammary tumors has been shown to induce PTPe expression. An alternative splicing event leads to a nervous tissue-specific chondroitin sulfate proteoglycan called phosphacan, which represents the amino terminal portion of PTP omega. PTP thet and PTP?share a conserved amino terminal 160 amino acid MAM domain which facilitates homophilic binding. PTP upsilon localizes to points of cell contact and may be involved in regulating the assembly and disassembly of cadherin/catenin complexes in vivo. PTPsigma contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. PTPsigma may also be involved in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. Function: Interacts with LAR-interacting protein LIP.1. Subunit: Interacts with PPFIA1, PPFIA2 and PPFIA3. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Detected in all tissues tested except for placenta and liver. Post-translational modifications: A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization. Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. Contains 8 fibronectin type-III domains. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 tyrosine-protein phosphatase domains. Database links: Entrez Gene: 5802 Human Omim: 601576 Human SwissProt: Q13332 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
蛋白酪氨酸磷酸酶，或称PTP，是I型跨膜蛋白、膜相关蛋白或定位于细胞核的蛋白质。跨膜PTP的例子是LAR、PTPα、PTPβ、PTPγ、PTPδ、PTPε、PTP_、PTPθ、PTP上升子和PTP。跨膜PTSPIGMA在发育和组织中起着不同的作用。免疫耗竭研究表明LAR是胰岛素受体磷酸化的调节因子。由于佛波酯的刺激，PTPα活性增加两倍，导致PKC家族成员直接或间接的丝氨酸磷酸化。在乳腺肿瘤中v-H-Ras和Neu的过度表达，但不是Myc或Int2，已被证明诱导PTPe的表达。另一种剪接事件导致神经组织特异性硫酸软骨素蛋白聚糖，称为磷酸酶，它代表PTP的氨基末端部分。PTP THT和PTP？共享一个保守的氨基末端160氨基酸MAM结构域，有利于嗜同性结合。PTP上游蛋白定位于细胞接触点，可能参与调节体内钙粘素/连环素复合物的组装与拆卸。PTPsigma包含细胞外区、单个跨膜段和两个串联的胞浆内催化结构域，因此代表受体型PTP。PTPSIGMA也可能参与神经修复的分子调控。四个交替剪接转录变体，编码不同的蛋白质，已被报道。