FITC标记的CNOT6蛋白抗体上海沪震实业有限公司

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产品名称: FITC标记的CNOT6蛋白抗体
英文名称: Anti-CNOT6/FITC
抗体货号: HZ-
产品规格: 100ul
级    别: , , 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/12/5 15:13:00
详细资料:  实验方法技术资料
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诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-CNOT6/FITC Conjugated antibody

FITC标记的CNOT6蛋白抗体

 

英文名称 Anti-CNOT6/FITC
中文名称 FITC标记的CNOT6蛋白抗体
别    名 carbon catabolite repression 4 protein; Carbon catabolite repressor protein 4 homolog; CCR4; CCR4 carbon catabolite repression 4 like; CCR4 carbon catabolite repression 4-like; CCR4-NOT transcription complex, subunit 6; CNOT6; Cytoplasmic deadenylase.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 63kDa
性    状 Lyophilized or Liquid
浓    度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CNOT6
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
CNOT6 is a widely expressed subunit of the CCR4-NOT transcription complex. The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription as well as mRNA degradation. Various subunits (e.g. CNOT1, CNOT3) are involved in influencing nuclear hormone receptor activities. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome. CNOT6 belongs to the CCR4/nocturin family and contains three LRR (leucine-rich) repeats. In the cytoplasm, CNOT6 acts as a poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the Fos gene.

Function:
Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as general transcription regulation complex (By similarity). In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. 

Subunit:
Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Interacts with UNR. Interacts with ZNF335. 

Subcellular Location:
Cytoplasmic and Nuclear.

Similarity:
Belongs to the CCR4/nocturin family. 
Contains 4 LRR (leucine-rich) repeats.

Database links:

Entrez Gene: 57472 Human

Entrez Gene: 104625 Mouse

Entrez Gene: 287249 Rat

Omim: 608951 Human

SwissProt: Q9ULM6 Human

SwissProt: Q8K3P5 Mouse

SwissProt: Q6AXU9 Rat

Unigene: 608380 Human

Unigene: 247113 Mouse

Unigene: 431753 Mouse

Unigene: 93562 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

CNOT6是CCR4-NO转录复合物广泛表达的亚基。CCR4-NOT复合物是进化上保守的多组分复合物,已知参与转录和mRNA降解。各种亚单位(例如CNOT1、CNOT3)参与影响核受体活性。CCR4-NOT复合物还通过可能涉及蛋白酶体的泛素依赖性途径参与组蛋白H3赖氨酸4甲基化的调节。CNOT6属于CCR4/夜曲素家族,包含三个LRR(富含亮氨酸)重复序列。在细胞质中,CNOT6是参与由Fos基因不稳定性的主要蛋白编码决定簇(mCRD)介导的mRNA衰变的多聚核酸酶。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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