FITC标记的尤文肉瘤FLI1蛋白抗体上海沪震实业有限公司

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产品名称: FITC标记的尤文肉瘤FLI1蛋白抗体
英文名称: Anti-FLI1/FITC
抗体货号: HZ-20433R-FITC
产品规格: 100ul
级    别: , , 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/12/5 15:16:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-FLI1/FITC Conjugated antibody

FITC标记的尤文肉瘤FLI1蛋白抗体

 

英文名称 Anti-FLI1/FITC
中文名称 FITC标记的尤文肉瘤FLI1蛋白抗体
别    名 ERGB transcription factor; Ewing Sarcoma breakpoint region 2; EWSR 2; EWSR2; FLI 1; FLI 1 proto oncogene; FLI1; FLI1 EWS fusion gene; FLI1 proto oncogene; FLI1_HUMAN; Friend leukemia integration 1 transcription factor; Friend leukemia virus integration 1; Proto-oncogene Fli-1; SIC 1; SIC1; Transcription factor ERGB; Viral integration region FLI1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  免疫学  染色质和核信号  细胞凋亡  细胞周期蛋白  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 50kDa
性    状 Lyophilized or Liquid
浓    度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human FLI1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Function:
Sequence-specific transcriptional activator. Recognizes the DNA sequence 5-C[CA]GGAAGT-3

Subunit:
Can form homodimers or heterodimers with ETV6/TEL1.

Subcellular Location:
Nucleus.

DISEASE:
Defects in FLI1 are a cause of Ewing sarcoma (ES) [MIM:612219]. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=A chromosomal aberration involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1.

Similarity:
Belongs to the ETS family.
Contains 1 ETS DNA-binding domain.
Contains 1 PNT (pointed) domain.

Database links:
Entrez Gene: 2313 Human
Entrez Gene: 14247 Mouse
Entrez Gene: 315532 Rat
Omim: 193067 Human
SwissProt: Q01543 Human
SwissProt: P26323 Mouse
Unigene: 504281 Human
Unigene: 258908 Mouse
Unigene: 203677 Rat

 


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

该基因编码含有ETS DNA结合结构域的转录因子。该基因可与Ewing肉瘤基因在22号染色体上发生t(11;22)(q24;q12)易位,导致大多数Ewing肉瘤病例中存在融合基因。一个急性淋巴细胞白血病相关t(4;11)(q21;q23)易位涉及该基因也被鉴定。选择性剪接导致多个转录变体。[ RefSeq,Aug 2012提供]

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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