FITC标记的跨膜蛋白SEMA5A抗体-抗体-抗体-生物在线
FITC标记的跨膜蛋白SEMA5A抗体

FITC标记的跨膜蛋白SEMA5A抗体

商家询价

产品名称: FITC标记的跨膜蛋白SEMA5A抗体

英文名称: Anti-Semaphorin 5A/FITC

产品编号: HZ-20430R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: ICC=1:50-200 IF=1:50-200

上海沪震实业有限公司
  • 联系人 : 鲍丽雯
  • 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
  • 邮编 : 200612
  • 所在区域 : 上海
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  • 邮箱 : www.shzbio.net

 Rabbit Anti-Semaphorin 5A/FITC Conjugated antibody 

FITC标记的跨膜蛋白SEMA5A抗体

 

文名称 Anti-Semaphorin 5A/FITC
中文名称 FITC标记的跨膜蛋白SEMA5A抗体
别    名 Semaphorin 5A; Semaphorin-5A; Semaphorin5A; SEMA5A; SEMAF; Semaphorin F; SEM5A_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  细胞膜蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 118kDa
性    状 Lyophilized or Liquid
浓    度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Semaphorin 5A
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.

Function:
Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis. 

Subunit:
Binds PLXNB3.

Subcellular Location:
Membrane; single-pass type I membrane protein

Similarity:
Belongs to the semaphorin family. 
Contains 1 PSI domain. 
Contains 1 Sema domain. 
Contains 7 TSP type-1 domains. 

Database links:

Entrez Gene: 9037 Human

Entrez Gene: 20356 Mouse

Omim: 609297 Human

SwissProt: Q13591 Human

SwissProt: Q62217 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

该基因属于信号素基因家族,该家族编码包含信号素结构域和多个血栓反应蛋白1型重复的膜蛋白。该家族成员参与神经发育过程中的轴突导向。这一基因被认为是自闭症易感基因。