FITC标记的轴索过度生长抑制因子受体/Nogo受体抗体
产品名称： FITC标记的轴索过度生长抑制因子受体/Nogo受体抗体
英文名称： Anti-Nogo R/FITC
产品编号： HZ-20486R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围：
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-Nogo R/FITC Conjugated antibody
FITC标记的轴索过度生长抑制因子受体/Nogo受体抗体
| 英文名称 | Anti-Nogo R/FITC |
| 中文名称 | FITC标记的轴索过度生长抑制因子受体/Nogo受体抗体 |
| 别 名 | NgR; Nogo-66 receptor; Nogor; NogoR; Nogo-R; Reticulon 4 receptor; Rtn4r; RTN4R_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 48kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Nogo R |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Axons are essential for neuronal communication but they do not regenerate after injury to the adult mammalian brain or spinal cord. Failed regeneration is due in part to the production of a potent axonal growth inhibitor, Nogo, by myelinating cells. The finding of a high affinity axonal receptor for the extracellular domain of Nogo provides the first insight into the basis of Nogo action. Disrupting the interaction of Nogo with the Nogo-66 receptor may facilitate axonal regeneration in vivo. The protein is dubbed the Nogo receptor because it binds with several other proteins that block neural growth. It is found to be ubiquitous in the brain and spinal cord. Function: Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development (By similarity). Subunit: Homomultimer. Interacts with LINGO1. Interacts with KIAA0319L. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Similarity: Belongs to the Nogo receptor family. Contains 8 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. Database links: Entrez Gene: 65078 Human Entrez Gene: 65079 Mouse Entrez Gene: 113912 Rat Omim: 605566 Human SwissProt: Q9BZR6 Human SwissProt: Q99PI8 Mouse SwissProt: Q99M75 Rat Unigene: 30868 Human Unigene: 40149 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
轴突对于神经元通讯是必不可少的，但它们在成年哺乳动物脑或脊髓损伤后不能再生。再生失败的部分原因是有髓细胞产生了一种有效的轴突生长抑制剂Nogo。对Nogo细胞外结构域的高亲和力轴突受体的发现提供了对Nogo作用基础的第一个洞察。破坏Nogo与Nogo-66受体的相互作用可以促进轴突在体内的再生。这种蛋白质被称为Nogo受体，因为它与几种其他阻止神经生长的蛋白质结合。它在脑和脊髓中普遍存在。