FITC标记的小核糖核蛋白N抗体
产品名称: FITC标记的小核糖核蛋白N抗体
英文名称: Anti-SNRPN/FITC
产品编号: HZ-8741R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-SNRPN/FITC Conjugated antibody
FITC标记的小核糖核蛋白N抗体
英文名称 | Anti-SNRPN/FITC |
中文名称 | FITC标记的小核糖核蛋白N抗体 |
别 名 | HCERN3; PWCR; RSMN_HUMAN; RT LI; RTLI; SM D; Sm N; Sm protein D; Sm protein N; Sm-D; Sm-N; Small nuclear ribonucleoprotein associated protein N; Small nuclear ribonucleoprotein polypeptide N; Small nuclear ribonucleoprotein-associated protein N; SMD; SmN; SNRNP N; snRNP-N; SNRNPN; SNRPN; SNURF SNRPN; Tissue specific splicing protein; Tissue-specific-splicing protein. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 细胞生物 转录调节因子 表观遗传学 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 25kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 2mg/1ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human SNRPN |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: This gene is located within the Prader-Willi Syndrome critical region on chromosome 15 and is imprinted and expressed from the paternal allele. It encodes a component of the small nuclear ribonucleoprotein complex, which functions in pre-mRNA processing and may contribute to tissue-specific alternative splicing. Alternative promoter use and alternative splicing result in a multitude of transcript variants encoding the same protein. Transcript variants that initiate at the CpG island-associated imprinting center may be bicistronic and also encode the SNRPN upstream reading frame protein (SNURF) from an upstream open reading frame. In addition, long spliced transcripts for small nucleolar RNA host gene 14 (SNHG14) may originate from the promoters at this locus and share exons with this gene. Alterations in this region are associated with parental imprint switch failure, which may cause Angelman syndrome or Prader-Willi syndrome. [provided by RefSeq, Mar 2017] Function: May be involved in tissue-specific alternative RNA processing events. Subcellular Location: Nucleus. Tissue Specificity: Expressed in brain and lymphoblasts. Similarity: Belongs to the snRNP SmB/SmN family. Database links: Entrez Gene: 780877 Cow Entrez Gene: 6638 Human Entrez Gene: 20646 Mouse Entrez Gene: 84704 Mouse Entrez Gene: 81781 Rat Omim: 182279 Human SwissProt: Q17QN3 Cow SwissProt: Q60HD3 Cynomolgus Monkey SwissProt: P63162 Human SwissProt: P63163 Mouse SwissProt: Q5R6I0 Orangutan SwissProt: P63164 Rat Unigene: 555970 Human Unigene: 564847 Human Unigene: 578619 Human Unigene: 585703 Human Unigene: 592473 Human Unigene: 621316 Human Unigene: 632166 Human Unigene: 728856 Human Unigene: 274995 Mouse Unigene: 11169 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因位于15号染色体上的Prader-Willi综合征关键区域,由父本等位基因印迹和表达。它编码小核糖核蛋白复合物的一个组成部分,在mRNA前处理中起作用,并可能有助于组织特异性的替代性剪接。选择性启动子的使用和选择性剪接导致许多编码相同蛋白的转录体变体。起始于CpG岛相关印迹中心的转录变体可以是双电子的,并且还编码来自上游开放阅读框架的SNRPN上游阅读框架蛋白(SNURF)。此外,小核仁RNA宿主基因14(SNHG14)的长剪接转录本可能起源于该位点的启动子,并与该基因共享外显子。这一区域的变化与父母的印记切换失败有关,这可能导致Angelman综合征或Prader-Willi综合征。〔RefSeq,2017〕