FITC标记的突触足蛋白2抗体上海沪震实业有限公司

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产品名称: FITC标记的突触足蛋白2抗体
英文名称: Anti-Synaptopodin 2/FITC
抗体货号: HZ-8743R-FITC
产品规格: 100ul
级    别: , , 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/12/6 11:21:00
详细资料:  实验方法技术资料
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诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
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产品详细描述

 Rabbit Anti-Synaptopodin 2/FITC Conjugated antibody

FITC标记的突触足蛋白2抗体

 

英文名称 Anti-Synaptopodin 2/FITC
中文名称 FITC标记的突触足蛋白2抗体
别    名 DKFZp686G051; Genethonin 2; Genethonin-2; Myopodin; striated muscle specific; Synaptopodin-2; SYNP2_HUMAN; SYNPO 2; Synpo2.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  信号转导  结合蛋白  细胞骨架  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 117kDa
性    状 Lyophilized or Liquid
浓    度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Synaptopodin 2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
SYNPO2 (Synaptopodin 2) is a Protein Coding gene. Diseases associated with SYNPO2 include Duchenne Muscular Dystrophy and Myopathy, Myofibrillar, 2. GO annotations related to this gene include actin binding and muscle alpha-actinin binding. An important paralog of this gene is SYNPO2L.

Function:
Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336).

Subcellular Location:
Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion. Localizes to the Z-disk in mature striated muscle. The nuclear export is XPO1-dependent (By similarity). Localized in a fiber-like pattern. partly overlapping with filamentous actin.

Tissue Specificity:
Skeletal muscle-specific.

DISEASE:
Down-regulated in muscle cell lines derived from patients with Duchenne muscular dystrophy (DMD).

Similarity:
Belongs to the synaptopodin family.
Contains 1 PDZ (DHR) domain.

Database links:

Entrez Gene: 171024 Human

Entrez Gene: 118449 Mouse

Entrez Gene: 499702 Rat

SwissProt: Q9UMS6 Human

SwissProt: Q91YE8 Mouse

Unigene: 655519 Human

Unigene: 317009 Mouse

Unigene: 34359 Mouse

Unigene: 474733 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

SypPO2(突触素2)是一种蛋白质编码基因。与SimPO2相关的疾病包括Duchenne型肌营养不良和肌病,肌原纤维,2。与此基因相关的注释包括肌动蛋白结合和肌肉α-肌动蛋白结合。这个基因的一个重要的同源词是SyPo2L。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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