FITC标记的突触足蛋白2抗体
产品名称: FITC标记的突触足蛋白2抗体
英文名称: Anti-Synaptopodin 2/FITC
产品编号: HZ-8743R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Synaptopodin 2/FITC Conjugated antibody
FITC标记的突触足蛋白2抗体
英文名称 | Anti-Synaptopodin 2/FITC |
中文名称 | FITC标记的突触足蛋白2抗体 |
别 名 | DKFZp686G051; Genethonin 2; Genethonin-2; Myopodin; striated muscle specific; Synaptopodin-2; SYNP2_HUMAN; SYNPO 2; Synpo2. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 肿瘤 细胞生物 信号转导 结合蛋白 细胞骨架 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Pig, Cow, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 117kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 2mg/1ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Synaptopodin 2 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: SYNPO2 (Synaptopodin 2) is a Protein Coding gene. Diseases associated with SYNPO2 include Duchenne Muscular Dystrophy and Myopathy, Myofibrillar, 2. GO annotations related to this gene include actin binding and muscle alpha-actinin binding. An important paralog of this gene is SYNPO2L. Function: Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). Subcellular Location: Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion. Localizes to the Z-disk in mature striated muscle. The nuclear export is XPO1-dependent (By similarity). Localized in a fiber-like pattern. partly overlapping with filamentous actin. Tissue Specificity: Skeletal muscle-specific. DISEASE: Down-regulated in muscle cell lines derived from patients with Duchenne muscular dystrophy (DMD). Similarity: Belongs to the synaptopodin family. Contains 1 PDZ (DHR) domain. Database links: Entrez Gene: 171024 Human Entrez Gene: 118449 Mouse Entrez Gene: 499702 Rat SwissProt: Q9UMS6 Human SwissProt: Q91YE8 Mouse Unigene: 655519 Human Unigene: 317009 Mouse Unigene: 34359 Mouse Unigene: 474733 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
SypPO2(突触素2)是一种蛋白质编码基因。与SimPO2相关的疾病包括Duchenne型肌营养不良和肌病,肌原纤维,2。与此基因相关的注释包括肌动蛋白结合和肌肉α-肌动蛋白结合。这个基因的一个重要的同源词是SyPo2L。