FITC标记的血栓调节蛋白抗体
产品名称: FITC标记的血栓调节蛋白抗体
英文名称: Anti-Thrombomodulin/FITC
产品编号: HZ-20396R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: Flow-Cyt=1:50-200
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Rabbit Anti-Thrombomodulin/FITC Conjugated antibody
FITC标记的血栓调节蛋白抗体
英文名称 | Anti-Thrombomodulin/FITC |
中文名称 | FITC标记的血栓调节蛋白抗体 |
别 名 | Thrombomodulin; CD 141; CD141; CD141 antigen; Fetomodulin; THBD; THRM; TM; AHUS 6; AHUS6; BDCA 3; BDCA3; THPH12; TRBM_HUMAN. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 心血管 细胞生物 神经生物学 血管内皮细胞 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Rabbit, |
产品应用 | Flow-Cyt=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 61kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 2mg/1ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Thrombomodulin |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: Thrombomodulin, TM is cell surface glycoprotein; plays an important role in the protein C anticoagulant pathway. It located in a vein, artery and capillary endothelial cells on the surface of plasma membrane protein. It is generally believed: TM vascular endothelial injury is an important parameter is the thrombin receptor, known in a variety of normal human tissues, can also be expressed in many tumors, TM may be similar to the E-cadherin,and is a lectin Like activity of a new class of members of the cell adhesion molecules. CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure. Function: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Endothelial cells are unique in synthesizing thrombomodulin. Post-translational modifications: N-glycosylated. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. DISEASE: Defects in THBD are the cause of thrombophilia due to thrombomodulin defect (THPH12) [MIM:614486]. A hemostatic disorder characterized by a tendency to thrombosis. Defects in THBD are a cause of susceptibility to hemolytic uremic syndrome atypical type 6 (AHUS6) [MIM:612926]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Similarity: Contains 1 C-type lectin domain. Contains 6 EGF-like domains. Database links: Entrez Gene: 7056 Human Omim: 188040 Human SwissProt: P07204 Human Unigene: 2030 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 血栓调节蛋白(thrombomodulin,TM)是一种分布于静脉、动脉和毛细血管内皮细胞表面的质膜蛋白。 一般认为:TM是血管内皮损伤的重要参数,也是凝血酶的受体,已知在人类多种正常组织中表达,亦可表达于许多肿瘤组织,TM可能类似于钙粘蛋白,是具有凝集素样活性的新一类细胞粘附分子的成员。TM是血管内皮细胞膜上的凝血酶受体之一。与凝血酶结合后可降低凝血酶的凝血活性,而加强其激活蛋白C的活性。由于被激活的蛋白C具有抗凝作用,因此,TM是使凝血酶由促凝转向抗凝的重要的血管内凝血抑制因子 |
血栓调节蛋白,TM是细胞表面糖蛋白,在蛋白C抗凝途径中起重要作用。它位于血管、动脉和毛细血管内皮细胞质膜蛋白表面。一般认为:TM是血管内皮损伤的一个重要参数,是凝血酶受体,已知在多种正常人体组织中,也可以在许多肿瘤中表达,TM可能与E-钙粘蛋白相似,是一种凝集素样活性的新型细胞粘附分子。SiON分子。