FITC标记的组蛋白去乙酰化酶9抗体上海沪震实业有限公司

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产品名称: FITC标记的组蛋白去乙酰化酶9抗体
英文名称: Anti-HDAC9/FITC
抗体货号: HZ-20554R-FITC
产品规格: 100ul
级    别: , , 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/12/6 14:35:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Rabbit Anti-HDAC9/FITC Conjugated antibody 

FITC标记的组蛋白去乙酰化酶9抗体

 

英文名称 Anti-HDAC9/FITC
中文名称 FITC标记的组蛋白去乙酰化酶9抗体
别    名 HD 7; HD 7B; HD 9; HD7; HD7B; HD9; HDAC 7; HDAC 7B; HDAC 9; HDAC 9B; HDAC 9FL; HDAC; HDAC7; HDAC7B; HDAC9B; HDAC9FL; HDRP; Histone deacetylase 4/5 related protein; Histone deacetylase 7; Histone deacetylase 7B; Histone deacetylase 9; Histone deacetylase 9A; Histone deacetylase related protein; KIAA0744; MEF2 interacting transcription repressor MITR; MEF2 interacting transcription repressor protein; MITR. DKFZp779K1053; HDAC9_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  免疫学  信号转导  细胞凋亡  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 111kDa
性    状 Lyophilized or Liquid
浓    度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human HDAC9
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
HDAC9 (Histone Deacetylase 9) catalyses the deacetylation of lysine residues on the core histones (H2A, H2B, H3 and H4). It belongs to the Class IIa HDAC family, which are key regulators of several developmental and differentiation processes such as cardiac growth. HDAC9 represses MEF2 (myocyte enhancer factor 2)-dependent transcription, playing an important role in cardiac hypertrophy.
The HDAC9 isoform MITR/HDRP lacks active site residues and is therefore catalytically inactive. It represses MEF2-dependent transcription by interacting with HDAC1 and/or HDAC3. MITR/HDRP is thought to play a role in skeletal myogenesis and in heart development. It also protects neurons from apoptosis by inhibiting c-Jun phosphorylation by MAPK10 and by repressing c-Jun transcription through recruitment of HDAC1 to the c-Jun promoter.

Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. 
Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.

Subunit:
Homodimer. Interacts with CTBP1. The phosphorylated form interacts with 14-3-3. Interacts with HDAC1 and HDAC3, and probably with HDAC4 and HDAC5. Interacts with MEF2, MAPK10, ETV6, NCOR1 and BCL6.

Subcellular Location:
Nucleus.

Tissue Specificity:
Broadly expressed, with highest levels in brain, heart, muscle and testis. Isoform 3 is present in human bladder carcinoma cells (at protein level). 

Post-translational modifications:
Phosphorylated on Ser-220 and Ser-450; which promotes 14-3-3-binding, impairs interaction with MEF2, and antagonizes antimyogenic activity. Phosphorylated on Ser-240; which impairs nuclear accumulation. Isoform 7 is phosphorylated on Tyr-1010. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. 
Sumoylated. 

DISEASE:
Note=A chromosomal aberration involving HDAC9 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with TGFB2 resulting in lack of HDAC9 protein. 

Similarity:
Belongs to the histone deacetylase family. HD type 2 subfamily. 

Database links:

Entrez Gene: 9734 Human

Entrez Gene: 79221 Mouse

Entrez Gene: 314040 Rat

Omim: 606543 Human

SwissProt: Q9UKV0 Human

SwissProt: Q99N13 Mouse

Unigene: 196054 Human

Unigene: 310551 Mouse

Unigene: 483009 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

HDAC9(组蛋白脱乙酰酶9)催化核心组蛋白(H2A、H2B、H3和H4)上赖氨酸残基的脱乙酰化。它属于IIa类HDAC家族,是心脏生长等发育和分化过程的关键调节因子。HDAC9抑制MEF2(心肌细胞增强因子2)依赖的转录,在心肌肥厚中起重要作用。

 

HDAC9异构体MITR/HDRP缺乏活性位点残基,因此催化失活。它通过与HDAC1和/或HDAC3相互作用抑制MEF2依赖的转录。MITR/HDRP被认为在骨骼肌发生和心脏发育中起作用。它还通过MAPK10抑制c-Jun***酸化以及通过将HDAC1募集到c-Jun启动子来抑制c-Jun转录来防止神经元凋亡。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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