Anti-phospho-Hck (Tyr411)抗体上海钰博生物科技有限公司

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产品名称: Anti-phospho-Hck (Tyr411)抗体
英文名称: phospho-Hck (Tyr411)
抗体货号: YB--16384R
产品规格: 20ul/50ul/100ul/200ul
级    别: 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 1580元
抗原: KLH conjugated synthesised phosphopeptide derived from human Hck around the phosphorylation site of Tyr411:NE(p-Y)TA
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Chicken, Cow, Horse, Sheep,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2018/12/6 14:41:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-phospho-Hck (Tyr411)抗体

产品编号 YB-16384R
英文名称 phospho-Hck (Tyr411)
中文名称 ***酸化造血细胞激酶抗体
别    名 Hck (phospho Y411); Hck (phospho Tyr411); Bmk; Hck 1; Hemopoietic cell kinase; Hemopoietic cell kinase isoform p59 Hck; JTK 9; JTK9; MGC 18625; MGC18625; p59 HCK/p60 HCK; p59HCK/p60HCK; Tyrosine protein kinase HCK; HCK_HUMAN.  
规格价格 100ul/1580元 购买        大包装/询价
说 明 书 100ul  
产品类型 ***酸化抗体 
研究领域 细胞生物  信号转导  生长因子和***  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Cow, Horse, Sheep, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 59kDa
细胞定位 细胞核 细胞浆 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human Hck around the phosphorylation site of Tyr411:NE(p-Y)TA 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
HCK is a tyrosine kinase that is predominantly expressed in hemopoietic cell types. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils.

Function:
May serve as part of a signaling pathway coupling the Fc receptor to the activation of the respiratory burst. May also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.

Subunit:
Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with VAV1, WAS and RAPGEF1. Interacts (via SH3 domain) with HIV-1 Nef and Vif. This interaction stimulates its tyrosine-kinase activity. Interacts (via SH3 domain) with HEV ORF3 protein. Interacts with ARRB1 and ARRB2. Interacts with ADAM15. Interacts with FASLG. Interacts with CBL. Interacts with FCGR1A; the interaction may be indirect. Interacts with IL6ST. Interacts (via SH3 domain) with ELMO1. Interacts (via SH3 domain) with TP73. Interacts with YAP1. Interacts with ABL1 and ITGB1, and thereby recruits ABL1 to activated ITGB1.

Subcellular Location:
Membrane. Cytoplasm. At least half of this isoform is found in the cytoplasm, some of this fraction is myristoylated and Membrane. Membrane > caveola. 20% of this isoform is associated with caveolae, this association depends on palmitoylation of cyteine at position 3.

Tissue Specificity:
Detected in monocytes and neutrophils (at protein level). Expressed predominantly in cells of the myeloid and B-lymphoid lineages. Highly expressed in granulocytes. Detected in tonsil. 

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family.
SRC subfamily.
Contains 1 protein kinase domain. 
Contains 1 SH2 domain.
Contains 1 SH3 domain.

SWISS:
P08631

Gene ID:
3055

Database links:

Entrez Gene: 3055 Human

Entrez Gene: 15162 Mouse

Entrez Gene: 25734 Rat

Omim: 142370 Human

SwissProt: P08631 Human

SwissProt: P08103 Mouse

SwissProt: P50545 Rat

Unigene: 655210 Human

Unigene: 715 Mouse

Unigene: 10945 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
 
产品图片
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (phospho-Hck(Tyr411)) Polyclonal Antibody, Unconjugated (bs-16384R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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