|别 名||Hck (phospho Y411); Hck (phospho Tyr411); Bmk; Hck 1; Hemopoietic cell kinase; Hemopoietic cell kinase isoform p59 Hck; JTK 9; JTK9; MGC 18625; MGC18625; p59 HCK/p60 HCK; p59HCK/p60HCK; Tyrosine protein kinase HCK; HCK_HUMAN.|
|规格价格||100ul/1580元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||细胞生物 信号转导 生长因子和*** 激酶和***酸酶|
|交叉反应||Human, Mouse, Rat, Chicken, Cow, Horse, Sheep,|
|产品应用||WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||59kDa|
|细胞定位||细胞核 细胞浆 细胞膜|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthesised phosphopeptide derived from human Hck around the phosphorylation site of Tyr411:NE(p-Y)TA|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
HCK is a tyrosine kinase that is predominantly expressed in hemopoietic cell types. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils.
May serve as part of a signaling pathway coupling the Fc receptor to the activation of the respiratory burst. May also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with VAV1, WAS and RAPGEF1. Interacts (via SH3 domain) with HIV-1 Nef and Vif. This interaction stimulates its tyrosine-kinase activity. Interacts (via SH3 domain) with HEV ORF3 protein. Interacts with ARRB1 and ARRB2. Interacts with ADAM15. Interacts with FASLG. Interacts with CBL. Interacts with FCGR1A; the interaction may be indirect. Interacts with IL6ST. Interacts (via SH3 domain) with ELMO1. Interacts (via SH3 domain) with TP73. Interacts with YAP1. Interacts with ABL1 and ITGB1, and thereby recruits ABL1 to activated ITGB1.
Membrane. Cytoplasm. At least half of this isoform is found in the cytoplasm, some of this fraction is myristoylated and Membrane. Membrane > caveola. 20% of this isoform is associated with caveolae, this association depends on palmitoylation of cyteine at position 3.
Detected in monocytes and neutrophils (at protein level). Expressed predominantly in cells of the myeloid and B-lymphoid lineages. Highly expressed in granulocytes. Detected in tonsil.
Belongs to the protein kinase superfamily. Tyr protein kinase family.
Contains 1 protein kinase domain.
Contains 1 SH2 domain.
Contains 1 SH3 domain.
Entrez Gene: 3055 Human
Entrez Gene: 15162 Mouse
Entrez Gene: 25734 Rat
Omim: 142370 Human
SwissProt: P08631 Human
SwissProt: P08103 Mouse
SwissProt: P50545 Rat
Unigene: 655210 Human
Unigene: 715 Mouse
Unigene: 10945 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.