Rabbit Anti-PODXL/FITC Conjugated antibody
|别 名||Podocalyxin; PCLP; PCLP1; podocalyxin-like isoform 1 precursor; Podocalyxin like protein; PODXL_HUMAN; GCTM-2 antigen; Gp200; Podocalyxin-like protein 1; PC; PCLP-1; PCX; PODXL.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||59kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human PODXL|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. [provided by RefSeq, Jul 2008]
Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
Apical cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Membrane raft. Membrane. In single attached epithelial cells is restricted to a preapical pole on the free plasma membrane whereas other apical and basolateral proteins are not yet polarized. Colocalizes with SLC9A3R2 at the apical plasma membrane during epithelial polarization. Colocalizes with SLC9A3R1 at the trans-Golgi network (transiently) and at the apical plasma membrane. Its association with the membrane raft is transient. Colocalizes with actin filaments, EZR and SLC9A3R1 in a punctate pattern at the apical cell surface where microvilli form. Colocalizes with EZR and SLC9A3R2 at the apical cell membrane of glomerular epithelium cells (By similarity). Forms granular, punctuated pattern, forming patches, preferentially adopting a polar distribution, located on the migrating poles of the cell or forming clusters along the terminal ends of filipodia establishing contact with the endothelial cells. Colocalizes with the submembrane actin of lamellipodia, particularly associated with ruffles. Colocalizes with vinculin at protrusions of cells. Colocalizes with ITGB1. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, RAB11A and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and luminogenesis.
Glomerular epithelium cell (podocyte).
Belongs to the podocalyxin family.
Entrez Gene: 5420 Human
Entrez Gene: 27205 Mouse
Entrez Gene: 482252 Dog
Omim: 602632 Human
SwissProt: Q52S86 Dog
SwissProt: O00592 Human
SwissProt: Q9R0M4 Mouse
Unigene: 732423 Human
Unigene: 89918 Mouse
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
这encodes of the唾液粘蛋白基因家族成员的蛋白质。编码的蛋白是originally as the important component of glomerular identified安足细胞。足细胞是高度分化和交错突细胞过程epithelial英尺覆盖显示glomerular of the the outer地下室膜。其他生物的活动，包括：of the编码蛋白与膜结合蛋白复合体中的Na + / H +交换体细胞骨架的调节因子intracellular元素，在造血细胞分化的角色，玩，和血管内皮细胞中被表达和结合的Selectin。[提供]序列模式，2008年7月