FITC标记的G蛋白信号转导调节因子20抗体
产品名称： FITC标记的G蛋白信号转导调节因子20抗体
英文名称： Anti-RGS20/FITC
产品编号： HZ-20516R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-RGS20/FITC Conjugated antibody
FITC标记的G蛋白信号转导调节因子20抗体
| 英文名称 | Anti-RGS20/FITC |
| 中文名称 | FITC标记的G蛋白信号转导调节因子20抗体 |
| 别 名 | G(z)GAP; Gz selective GTPase activating protein; Gz-GAP; Gz-selective GTPase-activating protein; HGNC:14600; Regulator of G protein signaling 20; Regulator of G-protein signaling 20; Regulator of G-protein signaling Z1; Regulator of Gz selective protein signaling 1; Regulator of Gz-selective protein signaling 1; RGS20; RGS20_HUMAN; RGSZ1; ZGAP1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 44kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RGS20 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins. Subcellular Location: Membrane. Nucleus. Cytoplasm. Shuttles between the cytoplasm/cell membrane and the nucleus (By similarity). Anchored to the membrane through palmitoylation. Tissue Specificity: Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe. Post-translational modifications: Fatty acylated. Heavily palmitoylated in the cysteine string motif. N- and O-glycosylated in synapsomal membranes. Serine phosphorylated in synapsomal membranes. Sumoylated by SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits. Similarity: Contains 1 RGS domain. Database links: Entrez Gene: 8601 Human Entrez Gene: 58175 Mouse Omim: 607193 Human SwissProt: O76081 Human SwissProt: Q9QZB1 Mouse Unigene: 368733 Human Unigene: 103771 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
该基因编码的蛋白属于G蛋白信号转导蛋白（RGS）的调节子家族，是G蛋白偶联受体复合物的调节和结构成分。RGS蛋白通过增加G蛋白α亚基的GTPase活性来抑制信号转导，从而迫使它们进入不活跃的GDP结合形式。该蛋白选择性地与G(z)-α和G(α)-i2亚基结合，并调节它们的信号转导活性。此外，还发现了编码不同异构体的剪接转录体变异体。[ RefSeq，SEP 2011提供]