|别 名||Unc 33 like phosphoprotein; Collapsin response mediator protein 4; Collapsin response mediator protein 4 long; CRMP 4; CRMP4; Dihydropyrimidinase like 3; Dihydropyrimidinase related protein 3; DPYSL3; DRP 3; DRP3; LCRMP; TUC4; Ulip 1; ULIP; ULIP1; UNc 33 like phosphoprotein 1; Unc 33 like phosphoprotein.|
|规格价格||100ul/1580元 购买 200ul/2480元 购买 大包装/询价|
|说 明 书||100ul 200ul|
|研究领域||细胞生物 免疫学 神经生物学|
|交叉反应||Human, Mouse, Rat, Dog, Cow, Horse, Sheep,|
|产品应用||ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||62kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human CRMP4/DRP3:465-570/570|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
The collapsin response mediator protein (CRMP) family of five cytosolic phosphoproteins are highly expressed throughout brain development. The functions of CRMPs encompass signal transduction in developmental guidance cues as well as multiple cellular and molecular events involved in apoptosis/proliferation, cell migration, and differentiation. In the adult brain, the expression of CRMPs is dramatically downregulated. However, CRMPs remain expressed in structures that retain their capacity for differentiation and plasticity. The expression of CRMPs is altered in neurodegenerative diseases, and these proteins may have a role in the physiopathology of the adult nervous system.
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).
Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5 (By similarity). Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin (By similarity).
Cytoplasmic. Cell projection, growth cone (By similarity). Note: Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone.
Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.
Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
Entrez Gene: 1809 Human
Entrez Gene: 22240 Mouse
Entrez Gene: 25418 Rat
Omim: 601168 Human
SwissProt: Q14195 Human
SwissProt: Q62188 Mouse
SwissProt: Q62952 Rat
Unigene: 519659 Human
Unigene: 428551 Mouse
Unigene: 8180 Mouse
Unigene: 93365 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications