Anti-Ube2G1抗体上海钰博生物科技有限公司

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产品名称: Anti-Ube2G1抗体
英文名称: Ube2G1
抗体货号: YB--8371R
产品规格: 20ul/50ul/100ul/200ul
级    别: 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 1580元
抗原: KLH conjugated synthetic peptide derived from human Ube2G1/UBC7:101-170/170
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/1/14 9:16:00
详细资料:  实验方法技术资料
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诚信指数:1562点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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上海钰博生物科技有限公司
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产品详细描述

 Anti-Ube2G1抗体

产品编号 YB-8371R
英文名称 Ube2G1
中文名称 泛素蛋白连接酶G1抗体
别    名 E217K; UB2G1_HUMAN; UBC 7; UBC7; UBC7 homolog yeast; UBE 2G; UBE2G; Ube2g1; Ubiquitin carrier protein G1; Ubiquitin conjugating enzyme E2 G1; Ubiquitin conjugating enzyme E2G 1 (homologous to C. elegans UBC7); Ubiquitin conjugating enzyme E2G 1 (UBC7 homolog C. elegans); Ubiquitin conjugating enzyme E2G 1 (UBC7 homolog yeast); Ubiquitin conjugating enzyme E2G 1; Ubiquitin protein ligase G1; Ubiquitin-conjugating enzyme E2 G1; Ubiquitin-protein ligase G1.  
规格价格 100ul/1580元 购买    200ul/2480元 购买    大包装/询价
说 明 书 100ul  200ul
研究领域 细胞生物  免疫学  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 19kDa
细胞定位 细胞浆 细胞外基质 分泌型蛋白 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Ube2G1/UBC7:101-170/170 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
Ubiquitin is an abundant, highly conserved protein found in all eukaryotic cells either free or covalently attached to cellular proteins. The primary function of ubiquitin in mammalian systems is to clear abnormal, foreign, and improperly folded proteins by targeting them for proteosome degradation. In Saccharomyces cerevisiae, ubiquitin-like proteins include Rub1, Ula1, Uba3, Smt3, Ubc2, Ubc12 and Ubc9. Rub1 shares 53% homology with ubiquitin and requires activation via the E2 proteins, including Ula1, Uba3 and Ubc12 in order to conjugate to substrates directed to different proteolytic systems. Ubc4 catalyzes ubiquitination of IkBa in a phosphorylation and SCFB-TRCP dependent manner. In this particular reaction, E1 first transfers ubiquitin to the E2 component Ubc4, and Ubc4 then associates with E3 ligase, which conjugates the poly-ubiquitin chain on a target protein. In this fashion, the chain tags the IkBa for degradation by a proteasome thus lifting the inhibitory effect of IkBa on NFkB and allowing NFkB to enter the nucleus.

Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.

Tissue Specificity:
Widely expressed, mainly in skeletal muscle.

Similarity:
Belongs to the ubiquitin-conjugating enzyme family.

SWISS:
P62253

Gene ID:
7326

Database links:

Entrez Gene: 7326 Human

Entrez Gene: 67128 Mouse

Omim: 601569 Human

SwissProt: P62253 Human

SwissProt: P62254 Mouse

Unigene: 727591 Human

Unigene: 741319 Human

Unigene: 458052 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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