Anti-UBE2E1抗体上海钰博生物科技有限公司

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产品名称: Anti-UBE2E1抗体
英文名称: UBE2E1
抗体货号: YB--8373R
产品规格: 20ul/50ul/100ul/200ul
级    别: 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 1580元
抗原: KLH conjugated synthetic peptide derived from human UBCH6/UBE2E1:1-100/193
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Mouse, Rat, Chicken, Pig, Cow, Sheep,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/1/14 9:17:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-UBE2E1抗体

产品编号 YB-8373R
英文名称 UBE2E1
中文名称 泛素蛋白连接酶E1抗体
别    名 UB2E1_HUMAN; UbcH6; UBE2E1; Ubiquitin carrier protein E1; Ubiquitin-conjugating enzyme E2 E1; Ubiquitin-protein ligase E1.  
Specific References  (1)     |     bs-8373R has been referenced in 1 publications.
[IF=1.87] Takenokuchi, Mariko, et al. "Bortezomib Causes ER Stress-related Death of Acute Promyelocytic Leukemia Cells Through Excessive Accumulation of PML–RARA." Anticancer Research 35.6 (2015): 3307-3316.  WB ;  Human.  
PubMed:26026090
 
规格价格 100ul/1580元 购买    200ul/2480元 购买    大包装/询价
说 明 书 100ul  200ul
研究领域  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse, Rat, Chicken, Pig, Cow, Sheep, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 21kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human UBCH6/UBE2E1:1-100/193 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires the ATP-dependent activation of the Ub C-terminus and the assembly of multi-Ub chains by the Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ub-conjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. UBE2E1 and UBE2L3, also designated UBCH6 and UBCH7 respectively in human, are E2 conjugating enzymes that interact with various proteins. Specifically, UBE2E1 interacts with the tumor suppressor protein TSSC5. UBE2L3 has been shown to mediate c-fos degradation, NF-kB maturation, human papilloma virus-mediated p53 and Myc protein degradation.

Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination.

Subunit:
Interacts with RNF14.

Subcellular Location:
Nucleus.

Post-translational modifications:
ISGylation suppresses ubiquitin E2 enzyme activity. 

Similarity:
Belongs to the ubiquitin-conjugating enzyme family. 

SWISS:
P51965

Gene ID:
7324

Database links:

Entrez Gene: 7324 Human

Entrez Gene: 22194 Mouse

Omim: 602916 Human

SwissProt: P51965 Human

SwissProt: P52482 Mouse

SwissProt: Q541Z5 Mouse

Unigene: 164853 Human

Unigene: 4429 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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