Anti-UBE2E1抗体
产品名称： Anti-UBE2E1抗体
英文名称： UBE2E1
产品编号： YB--8373R
产品价格： null
产品产地： 中国/美国
品牌商标： Ybscience
更新时间： 2023-08-17T10:29:50
使用范围： 科研使用
上海钰博生物科技有限公司
- 联系人 : 陈环环
- 地址 : 上海市沪闵路6088号龙之梦大厦8楼806室
- 邮编 : 200612
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- 传真 : 021-60514606
- 邮箱 : shybio@126.com
Anti-UBE2E1抗体
| 产品编号 | YB-8373R |
| 英文名称 | UBE2E1 |
| 中文名称 | 泛素蛋白连接酶E1抗体 |
| 别 名 | UB2E1_HUMAN; UbcH6; UBE2E1; Ubiquitin carrier protein E1; Ubiquitin-conjugating enzyme E2 E1; Ubiquitin-protein ligase E1. |
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Specific References (1) | bs-8373R has been referenced in 1 publications.
[IF=1.87] Takenokuchi, Mariko, et al. "Bortezomib Causes ER Stress-related Death of Acute Promyelocytic Leukemia Cells Through Excessive Accumulation of PML–RARA." Anticancer Research 35.6 (2015): 3307-3316. WB ; Human.
PubMed:26026090
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| 规格价格 | 100ul/1580元 购买 200ul/2480元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, Chicken, Pig, Cow, Sheep, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 21kDa |
| 细胞定位 | 细胞核 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human UBCH6/UBE2E1:1-100/193 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires the ATP-dependent activation of the Ub C-terminus and the assembly of multi-Ub chains by the Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ub-conjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. UBE2E1 and UBE2L3, also designated UBCH6 and UBCH7 respectively in human, are E2 conjugating enzymes that interact with various proteins. Specifically, UBE2E1 interacts with the tumor suppressor protein TSSC5. UBE2L3 has been shown to mediate c-fos degradation, NF-kB maturation, human papilloma virus-mediated p53 and Myc protein degradation. Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. Subunit: Interacts with RNF14. Subcellular Location: Nucleus. Post-translational modifications: ISGylation suppresses ubiquitin E2 enzyme activity. Similarity: Belongs to the ubiquitin-conjugating enzyme family. SWISS: P51965 Gene ID: 7324 Database links: Entrez Gene: 7324 Human Entrez Gene: 22194 Mouse Omim: 602916 Human SwissProt: P51965 Human SwissProt: P52482 Mouse SwissProt: Q541Z5 Mouse Unigene: 164853 Human Unigene: 4429 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |