Anti-alpha 2 Macroglobulin抗体
|英文名称||alpha 2 Macroglobulin|
|别 名||A2M; A2MG_HUMAN; Alpha 2 M; Alpha 2M; Alpha-2-M; Alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; CPAMD5; DKFZp779B086; FWP007; S863 7.|
|规格价格||50ul/880元 购买 100ul/1580元 购买 200ul/2480元 购买 大包装/询价|
|说 明 书||50ul 100ul 200ul|
|研究领域||细胞生物 免疫学 神经生物学|
|交叉反应||Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||160kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human alpha 2 Macroglobulin:751-850/1474|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008].
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Secreted in plasma
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
Entrez Gene: 2 Human
Entrez Gene: 232345 Mouse
Entrez Gene: 24153 Rat
Omim: 103950 Human
SwissProt: P01023 Human
SwissProt: Q61838 Mouse
SwissProt: P06238 Rat
Unigene: 212838 Human
Unigene: 30151 Mouse
Unigene: 225884 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
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