|别 名||Hig1; HIG1 domain family member 1A; HIG1 domain family, member 1A; HIG1 hypoxia inducible domain family, member 1A; HIG1A_HUMAN; HIGD1A; HIMP1; Hypoxia-inducible gene 1 protein.|
|规格价格||100ul/1580元 购买 200ul/2480元 购买 大包装/询价|
|说 明 书||100ul 200ul|
|研究领域||肿瘤 细胞生物 免疫学 细胞凋亡|
|交叉反应||Human, Mouse, Rat, Horse,|
|产品应用||ELISA=1:500-1000 IHC-F=1:400-800 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||10kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human HIG1/HIGD1A:25-70/93|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
HIGD1A (HIG1 domain family member 1A), also known as HIG1 (hypoxia-inducible gene 1 protein) or HSPC010, is a 93 amino acid multi-pass membrane protein that contains one HIG1 domain. Existing as two alternatively spliced isoforms, the gene encoding HIGD1A maps to human chromosome 3, which contains approximately 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.
Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes.
Associates with cytochrome c oxidase (COX, complex IV); proposed complex component. Also associates with respratory chain supercomplexes.
Mitochondrion membrane; Multi-pass membrane protein. Mitochondrion inner membrane (Probable).
Contains 1 HIG1 domain.
Entrez Gene: 25994 Human
Entrez Gene: 56295 Mouse
Entrez Gene: 140937 Rat
SwissProt: Q9Y241 Human
SwissProt: Q9JLR9 Mouse
SwissProt: Q8VH49 Rat
Unigene: 593134 Human
Unigene: 728813 Human
Unigene: 7917 Human
Unigene: 347915 Mouse
Unigene: 2084 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.