Anti-USP3抗体上海钰博生物科技有限公司

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产品名称: Anti-USP3抗体
英文名称: USP3
抗体货号: YB--4806R
产品规格: 20ul/50ul/100ul/200ul
级    别: 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 1580元
抗原: 免 疫 原KLH conjugated synthetic peptide derived from human USP3:31-130/520
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/4/23 14:20:00
详细资料:  实验方法技术资料
浏览人数:17
诚信指数:1658点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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上海钰博生物科技有限公司
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上海市沪闵路6088号龙之梦大厦8楼806室
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200612
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产品详细描述

 Anti-USP3抗体

产品编号 YB-4806R
英文名称 USP3
中文名称 去泛素化酶3抗体
别    名 Deubiquitinating enzyme 3; EC 3.1.2.15; SIH003; Ubiquitin carboxyl-terminal hydrolase 3; Ubiquitin specific peptidase 3; Ubiquitin specific processing protease 3; Ubiquitin Specific Protease 3; Ubiquitin thioesterase 3; Ubiquitin thiolesterase 3; Ubiquitin-specific-processing protease 3; UBP; UBP3_HUMAN; Usp3.  
规格价格 100ul/1580元 购买    200ul/2480元 购买    大包装/询价
说 明 书 100ul  200ul
研究领域 肿瘤  细胞生物  免疫学  染色质和核信号  信号转导  激酶和***酸酶  表观遗传学  泛素  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 59kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human USP3:31-130/520 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP3 (ubiquitin specific peptidase 3), also known as UBP or SIH003, is a 520 amino acid protein that contains one UBP-type zinc finger and belongs to the peptidase C19 family. Expressed ubiquitously with highest levels present in pancreas, USP3 catalyzes the conversion of a ubiquitin C-terminal thioester to a free ubiquitin and a thiol. The gene encoding USP3 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome.

Function:
Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin. 

Subunit:
Interacts (via UBP-type domain) with H2A; the interaction is less efficient than with monoubiquitinated H2A. 

Subcellular Location:
Nucleus. Localizes preferentially with monoubiquitinated H2A to chromatin.

Tissue Specificity:
Expressed in all tissues examined, with strongest expression in pancreas.

Similarity:
Belongs to the peptidase C19 family. USP3 subfamily.
Contains 1 UBP-type zinc finger.

SWISS:
Q9Y6I4

Gene ID:
9960

Database links:

Entrez Gene: 9960 Human

Entrez Gene: 235441 Mouse

Entrez Gene: 363084 Rat

GenBank: NM_006537 Human

GenBank: NM_144937 Mouse

Omim: 604728 Human

SwissProt: Q9Y6I4 Human

SwissProt: Q91W36 Mouse

SwissProt: A1L1I5 Rat

Unigene: 458499 Human

Unigene: 38976 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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