Anti-GRK3抗体-抗体-抗体-生物在线
Anti-GRK3抗体

Anti-GRK3抗体

商家询价

产品名称: Anti-GRK3抗体

英文名称: GRK3

产品编号: YB--11727R

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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  • 邮编 : 200612
  • 所在区域 : 上海
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  • 邮箱 : shybio@126.com

 Anti-GRK3抗体

产品编号 YB-11727R
英文名称 GRK3
中文名称 β肾上腺素能受体激酶2抗体
别    名 ADRBK2; Adrenergic, beta, receptor kinase 2; ARBK2_HUMAN; BARK2; Beta adrenergic receptor kinase 2; Beta ARK 2; Beta-adrenergic receptor kinase 2; Beta-ARK-2; EC 2.7.11.15; G protein coupled receptor kinase 3; G-protein-coupled receptor kinase 3.  
规格价格 50ul/880元 购买    100ul/1580元 购买    200ul/2480元 购买    大包装/询价
说 明 书 50ul  100ul  200ul
研究领域 免疫学  转录调节因子  G蛋白偶联受体  表观遗传学  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 80kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Adrbk2:301-365/688 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonist-mediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messenger-regulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1), two forms of Beta-adrenergic receptor kinase: GRK 2 (Beta ARK, Beta ARK1) and GRK 3 (Beta ARK2), IT-11 (GRK 4), GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.

Function:
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.

Similarity:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. 
GPRK subfamily. 
Contains 1 AGC-kinase C-terminal domain. 
Contains 1 PH domain. 
Contains 1 protein kinase domain. 
Contains 1 RGS domain.

SWISS:
P35626

Gene ID:
157

Database links:

Entrez Gene: 157 Human

Entrez Gene: 320129 Mouse

Omim: 109636 Human

SwissProt: P35626 Human

SwissProt: Q3UYH7 Mouse

Unigene: 657494 Human

Unigene: 285619 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications