Anti-P44/42 MAPK(ERK1/2) Monoclonal Antibody

品牌：solarbio | 货号：K000236M

商品货号：	商品品牌：	规格	基本售价：	选择规格
K000236M-50ul	solarbio	50ul	960.00元
K000236M-100ul	solarbio	100ul	1600.00元

英文名称	Anti-P44/42 MAPK(ERK1/2) Monoclonal Antibody
别名	ERK-1;ERK1;ERT2;HS44KDAP;HUMKER1A;p44-ERK1;p44-MAPK;P44ERK1;P44MAPK;PRKM3
应用	WB IHC
稀释比例	WB 1:1000-2000. IHC 1:100-200.
交叉反应	Human Mouse Rat
蛋白分子量	44/42kDa
Gene ID	5595
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Saturated ammonium sulfate precipitation
亚型	IgG1
免疫原	Synthetic Peptide
性状	液体
Public Immunogen Range	Synthetic Peptide
Subcellular Locations	Cytoplasm Nucleus
Swiss Prot	P27361/P28482
克隆号	6B1
克隆类型	Monoclonal Antibody
背景资料	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.