Anti-P44/42 MAPK(ERK1/2) Monoclonal Antibody北京索莱宝科技有限公司

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产品名称: Anti-P44/42 MAPK(ERK1/2) Monoclonal Antibody
英文名称: Anti-P44/42 MAPK(ERK1/2) Monoclonal Antibody
抗体货号: K000236M
产品规格: 50ul/100ul
级    别: ,
产品产地: 北京
品牌商标: Solarbio
价    格: 960/50ul\1600/100ul元
抗原: 现做
抗原来源: 
抗体来源: 
适用物种: 
应用范围: 
更新时间: 2019/5/25 16:29:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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北京索莱宝科技有限公司
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郭倩
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北京·北京
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产品详细描述

 

Anti-P44/42 MAPK(ERK1/2) Monoclonal Antibody

品牌:solarbio | 货号:K000236M
商品货号:商品品牌:规格基本售价:选择规格
K000236M-50ulsolarbio50ul960.00元
K000236M-100ulsolarbio100ul1600.00元
英文名称Anti-P44/42 MAPK(ERK1/2) Monoclonal Antibody
别名ERK-1;ERK1;ERT2;HS44KDAP;HUMKER1A;p44-ERK1;p44-MAPK;P44ERK1;P44MAPK;PRKM3
应用WB IHC
稀释比例WB 1:1000-2000. IHC 1:100-200.
交叉反应Human Mouse Rat
蛋白分子量44/42kDa
Gene ID5595
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法Saturated ammonium sulfate precipitation
亚型IgG1
免疫原Synthetic Peptide
性状液体
Public Immunogen RangeSynthetic Peptide
Subcellular LocationsCytoplasm Nucleus
Swiss ProtP27361/P28482
克隆号6B1
克隆类型Monoclonal Antibody
背景资料Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.

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