Anti-MICAL2抗体
产品名称: Anti-MICAL2抗体
英文名称: MICAL2
产品编号: YB--18933R
产品价格: null
产品产地: 中国/美国
品牌商标: Ybscience
更新时间: 2023-08-17T10:29:50
使用范围: 科研使用
上海钰博生物科技有限公司
- 联系人 : 陈环环
- 地址 : 上海市沪闵路6088号龙之梦大厦8楼806室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 183****2235
- 传真 : 021-60514606
- 邮箱 : shybio@126.com
Anti-MICAL2抗体
产品编号 | YB-18933R |
英文名称 | MICAL2 |
中文名称 | 黄素蛋白氧化还原酶MICAL2抗体 |
别 名 | flavoprotein oxidoreductase MICAL2; KIAA0750; MICAL2PV1; MICAL2PV2; microtubule associated monoxygenase, calponin and LIM domain containing 2; Molecule interacting with CasL protein 2; Protein-methionine sulfoxide oxidase MICAL2. |
规格价格 | 100ul/1580元 购买 200ul/2480元 购买 大包装/询价 |
说 明 书 | 100ul 200ul |
研究领域 | 细胞生物 免疫学 细胞骨架 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Rabbit, |
产品应用 | ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 127kDa |
细胞定位 | 细胞核 细胞浆 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human MICAL2:601-700/1124 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
PubMed | PubMed |
产品介绍 | background: MICAL2 is a 1,124 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains one LIM zinc-binding domain and one calponin-homology domain. Using FAD as a cofactor, MICAL2 interacts with Rab 1B, plexin-A4 and Vimentin and, via these interactions, may play a role in cytoskeletal regulation, specifically at intermediate filaments. MICAL2, which exists as two alternatively spliced isoforms, is expressed at high levels in heart and brain and at lower levels in ovary, skeletal muscle, liver, testis and kidney tissue. Function: Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA. Subunit: Interacts with VIM and PLXNA4 By similarity. Interacts with RAB1B. Subcellular Location: Cytoplasm; Nucleus; cytoskeleton. Similarity: Belongs to the Mical family. Contains 1 CH (calponin-homology) domain. Contains 1 LIM zinc-binding domain. SWISS: O94851 Gene ID: 9645 Database links: Entrez Gene: 534041 Cow Entrez Gene: 476858 Dog Entrez Gene: 9645 Human Entrez Gene: 320878 Mouse Entrez Gene: 365352 Rat Omim: 608881 Human SwissProt: F1MF74 Cow SwissProt: O94851 Human SwissProt: Q8BML1 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |