染色体区域稳定蛋白/核输出蛋白1/染色体区域稳定必需蛋白抗体北京博奥森生物技术有限公司

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产品名称: 染色体区域稳定蛋白/核输出蛋白1/染色体区域稳定必需蛋白抗体
英文名称: Anti-Exportin 1
抗体货号: bs-2953R
产品规格: 100ul
产品产地: 中国
品牌商标: Bioss
价    格: 1580元
抗原: Exportin 1
抗原来源: KLH conjugated synthetic peptide derived from huma
抗体来源: Rabbit
适用物种: Human,Mouse,Rat,Pig,
无conjugate:无
Isotype:IgG
应用范围: IHC-P:1:400-800 IHC-F:1:400-800 IF:1:100-500 ELISA:1:500-1000
更新时间: 2019/4/16 14:03:00
详细资料:  实验方法技术资料
浏览人数:7
诚信指数:1428点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

供应商联系卡

北京博奥森生物技术有限公司
地址:
北京市通州区马驹桥镇联东U谷西区四期67号楼
邮编:
101102
电话:
4009019800
传真:
010-58129612
联系人:
所在区域:
北京·北京
邮件:
公司展台:

产品详细描述

IHC-P:1:400-800 IHC-F:1:400-800  IF:1:100-500  ELISA:1:500-1000; CRM1 (chromosome region maintenance 1 protein homolog) mediates the nuclear export of cellular proteins (cargoes) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, CRM1 binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The direction of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. CRM1 also mediates the nuclear export of the Rev protein of HIV-1 and Rex protein of HTLV-1. It is involved in Rex dimerization, U3 snoRNA transport from Cajal bodies to nucleoli.
CRM1 is also involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. CRM1 is also involved in the regulation NFAT and AP-1.

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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