维甲酸调节核基质相关蛋白抗体北京博奥森生物技术有限公司

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性能参数

产品名称: 维甲酸调节核基质相关蛋白抗体
英文名称: Anti-CDT2
抗体货号: bs-7935R
产品规格: 100ul
产品产地: 中国
品牌商标: Bioss
价    格: 1580元
抗原: CDT2
抗原来源: KLH conjugated synthetic peptide derived from huma
抗体来源: Rabbit
适用物种: Human,Mouse,Rat,Dog,Pig,Horse,Sheep,
无conjugate:无
Isotype:IgG
应用范围: WB:1:500-2000 IHC-P:1:400-800 IHC-F:1:400-800 IF:1:100-500 ELISA:1:500-1000
更新时间: 2019/3/15 18:18:00
详细资料:  实验方法技术资料
浏览人数:5
诚信指数:1406点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

供应商联系卡

北京博奥森生物技术有限公司
地址:
北京市通州区马驹桥镇联东U谷西区四期67号楼
邮编:
101102
电话:
4009019800
传真:
010-58129612
联系人:
博奥森
所在区域:
北京·北京
邮件:
公司展台:

产品详细描述

WB:1:500-2000 IHC-P:1:400-800 IHC-F:1:400-800  IF:1:100-500  ELISA:1:500-1000; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.
Tissue specificity: Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the spleen and lymph node, and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the expression in NT2 cell.

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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