胚胎神经细胞NNAT抗体北京博奥森生物技术有限公司

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产品名称: 胚胎神经细胞NNAT抗体
英文名称: Anti-Neuronatin
抗体货号: bs-11519R
产品规格: 100ul
产品产地: 中国
品牌商标: Bioss
价    格: 1580元
抗原: Neuronatin
抗原来源: KLH conjugated synthetic peptide derived from huma
抗体来源: Rabbit
适用物种: Human,Mouse,Rat,Pig,Cow,Rabbit,
无conjugate:无
Isotype:IgG
应用范围: IHC-P:1:400-800 IHC-F:1:400-800 ICC:1:100-500 IF:1:100-500
更新时间: 2019/3/15 18:19:00
详细资料:  实验方法技术资料
浏览人数:5
诚信指数:1406点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

供应商联系卡

北京博奥森生物技术有限公司
地址:
北京市通州区马驹桥镇联东U谷西区四期67号楼
邮编:
101102
电话:
4009019800
传真:
010-58129612
联系人:
博奥森
所在区域:
北京·北京
邮件:
公司展台:

产品详细描述

IHC-P:1:400-800 IHC-F:1:400-800 ICC:1:100-500 IF:1:100-500  ; The paternally imprinted Neuronatin gene (NNAT) is initially expressed in rhombomeres and the pituitary gland and is later expressed more widely, but much less abundantly, in the central and peripheral nervous systems. The human NNAT gene maps to chromosome 20q11.23 and contains an imprinting region associated with morphological abnormalities and early neonatal lethality. Specifically, hypermethylation of the NNAT gene occurs in both myeloid and lymphoid acute pediatric leukemias and may inhibit NNAT expression. The Neuronatin protein consists of two isoforms, alpha and beta, which are the products of alternative splicing. The alpha form of the Neuronatin gene is encoded by three exons, whereas the beta form is missing the second exon. Neuronatin mRNA expression is abundant in undifferentiated PC-12 cells. Treatment of these cells with nerve growth factor (NGF), which contributes to neuronal differentiation, downregulates Neuronatin mRNA expression. NNAT (-) 1.9 PC-12 cells exhibit an increase in nigericin, rotenone and valinomcin sensitivity; NNAT transfection restores wild-type PC-12 resistance. These results suggests a potential protective role for Neuronatin against toxic insult during development. 

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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