Anti-HIF-1 beta抗体-抗体-抗体-生物在线
Anti-HIF-1 beta抗体

Anti-HIF-1 beta抗体

商家询价

产品名称: Anti-HIF-1 beta抗体

英文名称: HIF-1 beta

产品编号: YB--52092R

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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 Anti-HIF-1 beta抗体

产品编号 YB-52092R
英文名称 HIF-1 beta
中文名称 缺氧诱导因子1β/HIF-1β兔单克隆抗体
别    名 HIF1 beta; ARNT1; ARNT; HIF 1 beta; HIF-1 Beta; ARNT protein; Aryl Hydrocarbon Receptor Nuclear Translocator ; Dioxin Receptor; Dioxin receptor nuclear translocator; Drnt; HIF 1 beta;HIF 1beta; HIF1B; HIF1beta; Hypoxia Inducible Factor 1; Hypoxia inducible factor 1 beta; Tango; ARNT_HUMAN; Class E basic helix-loop-helix protein 2; bHLHe2; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta; HIF-1 β; HIF1-β; HIF 1-β; HIF-1-β; HIF 1 β; HIF1β; HIF1 β; HIF1-β; HIF 1β.  
规格价格 50/1580元 购买    100/2680元 购买        大包装/询价
说 明 书 50  100  
研究领域 肿瘤  心血管  染色质和核信号  转录调节因子  
抗体来源 Rabbit
克隆类型 Monoclonal
克 隆 号 3F5
交叉反应 Human, Mouse, Rat, 
产品应用 WB=1:500-2000 IHC-P=1:50-200 IHC-F=1:50-200 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 87kDa
细胞定位 细胞核 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HIF-1 beta: 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Function:
Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.

Subunit:
Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with AHR, AHRR, HIF1A and EPAS1/HIF2A as well as with other bHLH proteins. Interacts with TACC3. Interacts with NOCA7. Heterodimer with HIF1A.

Subcellular Location:
Nucleus.

Similarity:
Contains 1 bHLH (basic helix-loop-helix) domain. 
Contains 1 PAC (PAS-associated C-terminal) domain. 
Contains 2 PAS (PER-ARNT-SIM) domains.

SWISS:
P27540

Gene ID:
405

Database links:

Entrez Gene: 405 Human

Entrez Gene: 11863 Mouse

Entrez Gene: 25242 Rat

Omim: 126110 Human

SwissProt: P27540 Human

SwissProt: P53762 Mouse

SwissProt: P41739 Rat

Unigene: 632446 Human

Unigene: 250265 Mouse

Unigene: 10520 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications