Anti-FEZ1/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-FEZ1/FITC Conjugated抗体
英文名称: Anti-FEZ1/FITC
抗体货号: YB--9721R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human FEZ1
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/4/21 15:19:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-FEZ1/FITC Conjugated抗体

产品编号 YB-9721R-FITC
英文名称 Anti-FEZ1/FITC
中文名称 FITC标记的脑胚胎锌指样蛋白1抗体
别    名 Fasciculation and elongation protein zeta 1; Fasciculation and elongation protein zeta-1; Fez 1; Fez; Fez-like zinc finger protein; FEZ1; FEZ1_HUMAN; Fezl; Forebrain embryonic zinc-finger like protein; Zpf312; Zygin 1; Zygin I; Zygin-1; Zygin1; ZyginI.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  神经生物学  细胞周期蛋白  细胞分化  锌指蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FEZ1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Frequent loss of heterozygosity (LOH) at human chromosome 8p22-p21 is associated with various tumors including prostate and breast cancer. The 8p22-p21 region contains the FEZ1 gene, which is altered in tumors of the esophagus, prostate and breast. The FEZ1 protein (also known as leucine zipper putative tumor suppressor or LZTS1) contains a DNA-binding leucine zipper motif. FEZ1 is expressed in normal breast and prostate, but alterations in FEZ1 expression result in abnormal cell growth. The absence of FEZ1 expression is characteristic of breast and prostate cancer cell lines as well as primary breast and pro-state tumors. This absence of FEZ1 may be due to several factors, including mutations in the FEZ1 gene or hypermethylation of the CpG island flanking the FEZ1 promoter region. FEZ1 acts as a negative regulator of cell growth. During cell-cycle progression, FEZ1 localizes to microtubule components and is hyperphosphorylated by cAMP-dependent kinase.

Function:
May be involved in axonal outgrowth as component of thenetwork of molecules that regulate cellular morphology and axonguidance machinery. Able to restore partial locomotion and axonalfasciculation to C.elegans unc-76 mutants in germlinetransformation experiments. May participate in the transport ofmitochondria and other cargos along microtubules.

Subunit:
Homodimer; difulfide-linked. May form heterodimers withFEZ2. Interacts with the NH2-terminal variable region (V1) of PKCzeta and weakly with that of PKC epsilon (By similarity). Interactswith UBE4B. Interacts with SAP30L. Interacts with SCOC and ULK1;SCOC interferes with ULK1-binding to FEZ1. Directly interacts withSCOC and UVRAG. Stabilizes the interaction between SCOC and UVRAGduring amino acid starvation.

Subcellular Location:
Cytoplasm, cytoskeleton, centrosome. Cellmembrane (By similarity). Note=Co-localizes with both, alpha- andgamma-tubulin. Translocated from the plasma membrane to thecytoplasm by activation of the PKC zeta (By similarity).

Tissue Specificity:
Mainly expressed in brain.

Post-translational modifications:
Phosphorylated by protein kinase C zeta; which enhancesinteraction with UBE4B and polyubiquitination.
Polyubiquitinated in a UBE4B-dependent manner; which does notlead to proteasomal degradation and may be important for neurogenicactivity. Polyubiquitin linkage seems to be mainly through Lys-26.

Similarity:
Belongs to the zygin family.

Database links:

Entrez Gene: 9638 Human

Entrez Gene: 235180 Mouse

Entrez Gene: 81730 Rat

Omim: 604825 Human

SwissProt: Q99689 Human

SwissProt: Q8K0X8 Mouse

SwissProt: P97577 Rat

Unigene: 224008 Human

Unigene: 5264 Mouse

Unigene: 5468 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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