Anti-GRASP65/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-GRASP65/FITC Conjugated抗体
英文名称: Anti-GRASP65/FITC
抗体货号: YB--7802R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , , , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human GRASP65
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Xenopuslaevis
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/4/12 9:08:00
详细资料:  实验方法技术资料
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诚信指数:3558点
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-GRASP65/FITC Conjugated抗体

产品编号 YB-7802R-FITC
英文名称 Anti-GRASP65/FITC
中文名称 FITC标记的高尔基体外周膜蛋白p65抗体
别    名 Golgi peripheral membrane protein p65; Golgi phosphoprotein 5; Golgi reassembly and stacking protein 1; Golgi reassembly and stacking protein 65 kDa; Golgi reassembly stacking protein 1 65kDa; Golgi reassembly stacking protein 1; Golgi reassembly stacking protein of 65 kDa; Golgi reassembly-stacking protein 1; Golgi reassembly-stacking protein of 65 kDa; GOLPH 5; GOLPH5; Gorasp 1; Gorasp1; GORS1_HUMAN; GRASP 65; GRASP65; MGC118894; MGC118897; P65; FLJ23443.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  细胞凋亡  细胞周期蛋白  细胞自噬  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Xenopuslaevis
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GRASP65
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis. Also mediates, via its interaction with GM130, the docking of transport vesicles with the Golgi membranes.

Subunit:
Homodimer. Forms higher order oligomers under interphase but not mitotic conditions. Dimers of the protein on one membrane might be able to interact with dimers on another and so stack cisternae. Interacts with the C-terminus of GM130 under both mitotic and non-mitotic conditions. The interaction is critical for the correct targeting of both proteins to the cis-Golgi. The complex binds to the vesicle docking protein p115. Interacts with TMED2 and TMED3 (By similarity).

Subcellular Location:
Golgi apparatus, cis-Golgi network membrane;

Post-translational modifications:
Phosphorylated by CDC2/B1 and PLK kinases during mitosis. Phosphorylation cycle correlates with the cisternal stacking cycle. Phosphorylation of the homodimer prevents the association of dimmers into higher order oligomers, leading to cisternal unstacking.
Target for caspase-3 cleavage during apoptosis. The cleavage contributes to Golgi fragmentation and occurs very early in the execution phase of apoptosis (By similarity).

Similarity:
Belongs to the GORASP family.
Contains 1 PDZ (DHR) domain.

Database links:
 UniProtKB/Swiss-Prot: Q9BQQ3.3

Entrez Gene: 64689 Human

Omim: 606867 Human

SwissProt: Q9BQQ3 Human

Unigene: 613614 Human

Unigene: 721946 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applicatioNS

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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