Anti-CD105/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-CD105/FITC Conjugated抗体
英文名称: Anti-CD105/FITC
抗体货号: YB--6323R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from rabbit CD105
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Dog, Pig, Rabbit,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/4/16 10:02:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-CD105/FITC Conjugated抗体

产品编号 YB-6323R-FITC
英文名称 Anti-CD105/FITC
中文名称 FITC标记的CD105抗体
别    名 END; Endoglin; ENG; FLJ41744; HHT1; ORW; ORW1; Osler Rendu Weber syndrome 1; RP11 228B15.2; CD 105; CD105 antigen; EGLN_HUMAN.  
Journal
PMID
IF
Application
BMC veterinary research (2012)
22937862
1.8600
FAC
 
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  心血管  细胞生物  信号转导  干细胞  生长因子和***  细胞表面分子  血管内皮细胞  内皮细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Dog, Pig, Rabbit, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 63kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from rabbit CD105
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]

Function:
Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.

Subunit:
Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4. Interacts with ARRB2.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Endoglin is restricted to endothelial cells in all tissues except bone marrow.

DISEASE:
Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.

Database links:

 

Entrez Gene: 2022 Human

Entrez Gene: 13805 Mouse

Entrez Gene: 497010 Rat

Omim: 131195 Human

SwissProt: P17813 Human

SwissProt: Q63961 Mouse

Unigene: 76753 Human

Unigene: 225297 Mouse

Unigene: 187025 Rat

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

CD105(Endoglin):CD105是一种存在于细胞表面的同源二聚体跨膜糖蛋白,是TGF-β受体复合物的组成部分,是TGF-β的附属受体,能与多种TGF-β超家族成员结合尤其与TGF-β1、TGF-β3有很高的亲和力,调节TGF-βs与其受体结合而参与信号传导,是内皮细胞增殖相关膜抗原,在培养的高增殖活性内皮细胞和许多恶性肿瘤组织血管内皮细胞中高表达,参与血管生成,但其在血管生成调节中的作用机制尚未阐明。主要用于各种恶性肿瘤组织中的血管生成的研究

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