Anti-LECT1/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-LECT1/FITC Conjugated抗体

Anti-LECT1/FITC Conjugated抗体

商家询价

产品名称: Anti-LECT1/FITC Conjugated抗体

英文名称: Anti-LECT1/FITC

产品编号: YB--7516R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
  • 联系人 : 陈环环
  • 地址 : 上海市沪闵路6088号龙之梦大厦8楼806室
  • 邮编 : 200612
  • 所在区域 : 上海
  • 电话 : 183****2235
  • 传真 : 021-60514606
  • 邮箱 : shybio@126.com

 Anti-LECT1/FITC Conjugated抗体

产品编号 YB-7516R-FITC
英文名称 Anti-LECT1/FITC
中文名称 FITC标记的白细胞衍生化学吸引素抗体
别    名 Chondromodulin I; BRICD3; BRICHOS domain containing 3; CHM I; CHM1; chondromodulin; Chondrosurfactant protein; LECT 1; Leukocyte cell derived chemotaxin 1; LECT1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  心血管  细胞生物  免疫学  细胞周期蛋白  细胞骨架  细胞外基质  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Guinea Pig, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 14kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LECT1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The LECT1 gene encodes a glycosylated transmembrane protein which is cleaved to form a mature, secreted protein. The N terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein, although no biological activity has yet been defined for it. The C terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell derived chondromodulin 1 or chemotaxin 1. The mature protein inhibits angiogenesis and promotes chondrocyte growth. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms.

Function:
Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development.

Subcellular Location:
Chondromodulin-1: Secreted. Note=Accumulated in the inter-territorial matrix of cartilage. Chondrosurfactant protein: Endomembrane system; Single-pass membrane protein (Potential).

Tissue Specificity:
Cartilage specific. Weakly expressed in chondrosarcoma.

Similarity:
Belongs to the chondromodulin-1 family.
Contains 1 BRICHOS domain. 

Database links:

UniProtKB/Swiss-Prot: O75829.1

  • Entrez Gene: 11061 Human
  • Entrez Gene: 16840 Mouse
  • Omim: 605147 Human
  • SwissProt: O75829 Human
  • SwissProt: Q9Z1F6 Mouse
  • Unigene: 421391 Human
  • Unigene: 46561 Mouse

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.