Anti-phospho-Caveolin-2 (Tyr19)/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-phospho-Caveolin-2 (Tyr19)/FITC Conjugated抗体

Anti-phospho-Caveolin-2 (Tyr19)/FITC Conjugated抗体

商家询价

产品名称: Anti-phospho-Caveolin-2 (Tyr19)/FITC Conjugated抗体

英文名称: Anti-phospho-Caveolin-2 (Tyr19)/FITC

产品编号: YB--7523R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

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 Anti-phospho-Caveolin-2 (Tyr19)/FITC Conjugated抗体

产品编号 YB-7523R-FITC
英文名称 Anti-phospho-Caveolin-2 (Tyr19)/FITC
中文名称 FITC标记的磷酸化细胞质膜微囊蛋白-2抗体
别    名 Caveolin 2 (phospho Y19); p-Caveolin 2(phospho Y19); CAV; CAV2; CAV2_HUMAN; Caveolae protein 20 kD; Caveolin 2; Caveolin 2 isoform a and b; Caveolin 2 isoform c; Caveolin-2; MGC12294; CAV2_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 磷酸化抗体 
研究领域 心血管  细胞生物  信号转导  细胞凋亡  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse, Rat, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 18kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from mouse Caveolin2 around the phosphorylation site of Tyr19.
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Cellular localization: Nucleus. Cytoplasm. Golgi apparatus membrane. Cell membrane. Membrane > caveola. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.

Function:
May act as a scaffolding protein within caveolarmembranes. Interacts directly with G-protein alpha subunits and canfunctionally regulate their activity. Acts as an accessory proteinin conjunction with CAV1 in targeting to lipid rafts and drivingcaveolae formation. The Ser-36 phosphorylated form has a role inmodulating mitosis in endothelial cells. Positive regulator ofcellular mitogenesis of the MAPK signaling pathway. Required forthe insulin-stimulated nuclear translocation and activation ofMAPK1 and STAT3, and the subsequent regulation of cell cycleprogression (By similarity).

Subunit:
Monomer or homodimer. Interacts with CAV1; theinteraction forms a stable heterooligomeric complex that isrequired for targeting to lipid rafts and for caveolae formation.Tyrosine phosphorylated forms do not form heterooligomers with theTyr-19-phosphorylated form existing as a monomer or dimer, and theTyr-27-form as a monomer only. Interacts (tyrosine phosphorylatedform) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC.Interacts (tyrosine phosphorylated form) with INSR, the interaction(Tyr-27-phosphorylated form) is increased on insulin stimulation.Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylatedform); the interaction, promoted by insulin, leads to nuclearlocation and MAPK1 activation. Interacts with STAT3; theinteraction is increased on insulin-induced tyrosinephosphorylation leading to STAT activation (By similarity).

Subcellular Location:
Nucleus. Cytoplasm. Golgi apparatusmembrane; Peripheral membrane protein. Cell membrane; Peripheralmembrane protein. Membrane, caveola; Peripheral membrane protein.Note=Potential hairpin-like structure in the membrane. Membraneprotein of caveolae. Tyr-19-phosphorylated form is enriched atsites of cell-cell contact and is translocated to the nucleus incomplex with MAPK1 in response to insulin (By similarity).Tyr-27-phosphorylated form is located both in the cytoplasm andplasma membrane. CAV1-mediated Ser-23-phosphorylated form locatesto the plasma membrane. Ser-36-phosphorylated form resides inintracellular compartments.

Tissue Specificity:
Expressed in endothelial cells, smooth musclecells, skeletal myoblasts and fibroblasts.

Post-translational modifications:
Phosphorylated on serine and tyrosine residues. CAV1 promotesphosphorylation on Ser-23 which then targets the complex to theplasma membrane, lipid rafts and caveolae. Phosphorylation onSer-36 appears to modulate mitosis in endothelial cells (Bysimilarity). Phosphorylation on both Tyr-19 and Tyr-27 is requiredfor insulin-induced 'Ser-727' phosphorylation of STAT3 and itsactivation. Phosphorylation on Tyr-19 is required forinsulin-induced phosphorylation of MAPK1 and DNA binding of STAT3.Tyrosine phosphorylation is induced by both EGF and insulin (Bysimilarity).

Similarity:
Belongs to the caveolin family.

Database links:

Entrez Gene: 858 Human

Entrez Gene: 12390 Mouse

Entrez Gene: 100362824 Rat

Entrez Gene: 363425 Rat

Omim: 601048 Human

SwissProt: P51636 Human

SwissProt: Q9WVC3 Mouse

SwissProt: Q2IBC5 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

Caveolin是细胞生长相关信号途径及肿瘤发生发展过程中重要的抑制因子,Caveolae是细胞膜内的特殊膜结构,参与包括细胞的分子运输、细胞粘附和信号转导在内的多种细胞活动。Caveolin-1是Caveolae中重要的结构蛋白,抑制细胞生长,与多种人类肿瘤发生发展相关的信号分子相互作用。Caveolin在信号转导的整合中起支架蛋白的作用。Caveolin构成了一个蛋白家族,他们是细胞质膜中发夹样结构域的主要结构成分。Caveolin在信号转导的整合中起支架蛋白的作用。至今已经鉴定了3种Caveolin (Caveolin-1、2 和3),它们具有不同的组织分布