Anti-Plakophilin 1/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-Plakophilin 1/FITC Conjugated抗体

Anti-Plakophilin 1/FITC Conjugated抗体

商家询价

产品名称: Anti-Plakophilin 1/FITC Conjugated抗体

英文名称: Anti-Plakophilin 1/FITC

产品编号: YB--7505R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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  • 邮箱 : shybio@126.com

 Anti-Plakophilin 1/FITC Conjugated抗体

产品编号 YB-7505R-FITC
英文名称 Anti-Plakophilin 1/FITC
中文名称 FITC标记的桥粒斑菲素蛋白1抗体
别    名 B6P; Band 6 protein; Plakophilin 1 (ectodermal dysplasia/skin fragility syndrome); PKP1_HUMAN.   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 心血管  细胞生物  免疫学  神经生物学  信号转导  细胞粘附分子  细胞外基质  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 83kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Plakophilin 1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Plays a role in formation of desmosomal plaques and is found in desmosomes of most simple and stratified epithelia. Not found in cell types that have non-epithelial desmosomes. Absent in fibroblasts and other connective tissue types, including sarcomas.

Function:
Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis.

Subcellular Location:
Nucleus. Cell junction, desmosome. Note: Nuclear and associated with desmosomes.

Tissue Specificity:
Isoform 2 is widely expressed. Isoform 1 is expressed in stratified squamous, complex, glandular duct and bladder epithelia.

DISEASE:
Defects in PKP1 are the cause of ectodermal dysplasia-skin fragility syndrome (EDSFS) [MIM:604536]; also known as McGrath syndrome. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSFS is characterized by features of both cutaneous fragility and congenital ectodermal dysplasia affecting abnormalities in other epithelia or tissues. Desmosomes in the skin are small and poorly formed with widening of keratinocyte intercellular spaces and perturbed desmosome/keratin intermediate filament interactions.

Similarity:
Belongs to the beta-catenin family.
Contains 9 ARM repeats. 

Database links:

UniProtKB/Swiss-Prot: Q13835.2

Entrez Gene: 5317 Human

Entrez Gene: 18772 Mouse

Omim: 601975 Human

SwissProt: Q13835 Human

SwissProt: P97350 Mouse

Unigene: 497350 Human

Unigene: 4494 Mouse

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.