Anti-GLMN/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-GLMN/FITC Conjugated抗体
英文名称: Anti-GLMN/FITC
抗体货号: YB--7030R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human GLMN/FK506 binding protein associated protein
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Dog, Pig, Horse,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/4/16 10:42:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-GLMN/FITC Conjugated抗体

产品编号 YB-7030R-FITC
英文名称 Anti-GLMN/FITC
中文名称 FITC标记的FK506结合蛋白相关蛋白抗体(他克莫司相关蛋白)
别    名 FAP; FAP48; FAP68; FK506 binding protein associated protein; FKBP associated protein; FKBPAP; GLML; GLMN; Glomulin; GVM; VMGLOM.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 干细胞  血管内皮细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Horse, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 68 kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GLMN/FK506 binding protein associated protein
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
GLMN is a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Alternatively spliced variants that encode different protein isoforms have been described but the full length nature of only one has been determined. GLMN may represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12 and may function as an membrane anchoring protein. Isoform 1 may stimulate the p70S6K pathway. Isoform 2 may inhibit cell proliferation and increase IL2 production.

Function:
Essential for normal development of the vasculature. May represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12. May function as an membrane anchoring protein. Isoform 1 may stimulate the p70S6K pathway. Isoform 2 may inhibit cell proliferation and increase IL2 production. 

Subunit:
Monomer. Isoform 1 interacts with notphosphorylated MET and is released upon receptor phosphorylation. Isoform 2 interacts with FKBP59 and FKBP12. Isoform 1 is part of a SCF-like complex consisting of CUL7, RBX1, SKP1, FBXW8 and GLMN isoform 1. 

Tissue Specificity:
Ubiquitous. 

Post-translational modifications:
Phosphorylated on tyrosine residues. 

DISEASE:
Defects in GLMN are the cause of glomuvenous malformations (GVMs) [MIM:138000]. GVMs are characterized by the presence of smooth-muscle-like glomus cells in the media surrounding distended vascular lumens. 

Database links:

Entrez Gene: 504211 Cow

Entrez Gene: 11146 Human

Entrez Gene: 170823 Mouse

GenBank: NP_444504.1 Human

Omim: 601749 Human

SwissProt: Q92990 Human

SwissProt: Q8BZM1 Mouse

Unigene: 49105 Human

Unigene: 41417 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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