Anti-phospho-GSK3 Alpha (Ser21)/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-phospho-GSK3 Alpha (Ser21)/FITC Conjugated抗体
英文名称: Anti-phospho-GSK3 Alpha (Ser21)/FITC
抗体货号: YB--4692R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthesised phosphopeptide derived from human GSK3 Alpha around the phosphorylation site of Ser21
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Chicken, Dog, Pig, Horse,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/4/16 10:45:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-phospho-GSK3 Alpha (Ser21)/FITC Conjugated抗体

产品编号 YB-4692R-FITC
英文名称 Anti-phospho-GSK3 Alpha (Ser21)/FITC
中文名称 FITC标记的***酸化糖原合酶激酶-3α抗体
别    名 GSK3 Alpha (phospho-Ser21); GSK3 Alpha (phospho Ser21); GSK3 Alpha (phospho S21); Gsk3a; GSK 3 alpha; GSK-3 alpha; GSK3 alpha; Glycogen synthase kinase-3 alpha; GSK 3 alpha; DKFZp686D0638; GSK 3A; GSK3A; GSK3alpha; GSK3A_HUMAN; Glycogen synthase kinase 3 alpha; Serine/threonine-protein kinase GSK3A.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 ***酸化抗体 
研究领域  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Horse, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 54kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human GSK3 Alpha around the phosphorylation site of Ser21
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily; GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. *** stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility. 

Function:
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transctiption factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth.

Subunit:
Monomer. Interacts with ARRB2. Interacts with AXIN1 and CTNNB1/beta-catenin.

Post-translational modifications:
Phosphorylated by AKT1 at Ser-21: upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and desactivates GSK3A, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-279

Similarity:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 2931 Human

Entrez Gene: 606496 Mouse

Entrez Gene: 50686 Rat

Omim: 606784 Human

SwissProt: P49840 Human

SwissProt: Q2NL51 Mouse

SwissProt: P18265 Rat

Unigene: 466828 Human

Unigene: 294664 Mouse

Unigene: 36807 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

GSK-3α和GSK-3β,在细胞和组织中广泛存在,参与多个信号通路的排列,包括糖原合成和细胞黏附作用

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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