Anti-phospho-Kidins220 (Ser918)/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-phospho-Kidins220 (Ser918)/FITC Conjugated抗体

Anti-phospho-Kidins220 (Ser918)/FITC Conjugated抗体

商家询价

产品名称: Anti-phospho-Kidins220 (Ser918)/FITC Conjugated抗体

英文名称: Anti-phospho-Kidins220 (Ser918)/FITC

产品编号: YB--7041R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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  • 邮箱 : shybio@126.com

 Anti-phospho-Kidins220 (Ser918)/FITC Conjugated抗体

产品编号 YB-7041R-FITC
英文名称 Anti-phospho-Kidins220 (Ser918)/FITC
中文名称 FITC标记的磷酸化220kDa蛋白激酶D相互作用蛋白抗体
别    名 Kidins220 (phospho S918); Ankyrin repeat-rich membrane-spanning protein; arms; KDIS_HUMAN; Kidins220; Kinase D interacting substance of 220 kDa; Kinase D-interacting substrate of 220 kDa; rgd 619949.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 磷酸化抗体 
研究领域 心血管  细胞生物  免疫学  神经生物学  信号转导  转录调节因子  激酶和磷酸酶  细胞膜受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, Guinea Pig, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 196kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human Kidins220 around the phosphorylation site of Ser918
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

Function:
’Promotes a prolonged MAP-kinase signaling byneurotrophins through activation of a Rap1-dependent mechanism.Provides a docking site for the CRKL-C3G complex, resulting inRap1-dependent sustained ERK activation. May play an important rolein regulating postsynaptic signal transduction through thesyntrophin-mediated localization of receptor tyrosine kinases suchas EPHA4. In cooperation with SNTA1 can enhance EPHA4-inducedJAK/STAT activation. May play a role in neurotrophin- andephrin-mediated neuronal outgrowth and in axon guidance duringneural development and in neuronal regeneration (By similarity).Modulates stress-induced apoptosis of melanoma cells via regulationof the MEK/ERK signaling pathway.

Subunit:
nteracts with NTRK1, NTRK2, NTRK3, ERKL and NGFR. Canform a ternary complex with NGFR and NTRK1 and this complex isaffected by the expression levels of KIDINS220/ARMS. An increase inKIDINS220/ARMS expression leads to a decreased association of NGFRand NTRK1. Interacts with SNTA1 and SNTB2 and binds to their PDZdomains. Interacts with EPHA4 and PRKD1 (By similarity).

Subcellular Location:
Membrane.

Tissue Specificity:
Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.

Post-translational modifications:
Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4.Phosphorylation at Ser-918 is induced by phorbol ester treatment.Phosphorylation by NTRK2 is induced by brain-derived neurotrophicfactor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 isinduced by nerve growth factor (NGF) (By similarity).

Similarity:
Contains 12 ANK repeats.
Contains 1 KAP NTPase domain.

Database links:

Entrez Gene: 57498 Human

Entrez Gene: 77480 Mouse

Entrez Gene: 116478 Rat

SwissProt: Q9ULH0 Human

SwissProt: Q9EQG6 Rat

Unigene: 9873 Human

Unigene: 250641 Mouse

Unigene: 21470 Rat

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications