Anti-Syncytin 1/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-Syncytin 1/FITC Conjugated抗体
英文名称: Anti-Syncytin 1/FITC
抗体货号: YB--2962R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human Syncytin 1
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/4/16 11:04:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-Syncytin 1/FITC Conjugated抗体

产品编号 YB-2962R-FITC
英文名称 Anti-Syncytin 1/FITC
中文名称 FITC标记的合胞素1抗体
别    名 HERV-W_7q21.2 provirus ancestral Env polyprotein; Endogenous retrovirus group W member 1; env; Env-W; Envelope polyprotein gPr73; Enverin; ENW1_HUMAN; ERVW; ERVW-1; Gp24; Gp50; HERV-7q Envelope protein; HERV-W envelope protein; HERVW; SU; Syncytin 1; Syncytin; Syncytin-1; TM; Transmembrane protein; Surface protein.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  微生物学  细菌及病毒  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, 
产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 33/58kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Syncytin 1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis.
SU mediates receptor recognition. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide (By similarity). Seems to recognize the type D mammalian retrovirus receptors SLC1A4 and SLC1A5, as it induces fusion of cells expressing these receptors in vitro.
The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes.

Function:
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis.
SU mediates receptor recognition. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide (By similarity). Seems to recognize the type D mammalian retrovirus receptors SLC1A4 and SLC1A5, as it induces fusion of cells expressing these receptors in vitro.
The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes (By similarity). 

Subunit:
The mature envelope protein (Env) consists of a trimer of SU-TM heterodimers attached probably by a labile interchain disulfide bond. Interacts with the C-type lectin CD209/DC-SIGN.

Subcellular Location:
Transmembrane protein: Cell membrane; Single-pass type I membrane protein (By similarity).
Surface protein: Cell membrane; Peripheral membrane protein (By similarity). Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM (By similarity).
HERV-W_7q21.2 provirus ancestral Env polyprotein: Virion (By similarity).

Tissue Specificity:
Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia.

Post-translational modifications:
Specific enzymatic cleavages in vivo yield mature proteins. Envelope glycoproteins are synthesized as a inactive precursor that is heavily N-glycosylated and processed likely by furin in the Golgi to yield the mature SU and TM proteins. The cleavage site between SU and TM requires the minimal sequence [KR]-X-[KR]-R. The intracytoplasmic tail cleavage by the viral protease that is required for the fusiogenic activity of some retroviruses envelope proteins seems to have been lost during evolution.
The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion (By similarity). 

Similarity:
Belongs to the gamma type-C retroviral envelope protein family. HERV class-I W env subfamily.

Database links:

Entrez Gene: 2086 Human

Entrez Gene: 30816 Human

Entrez Gene: 405754 Human

Omim: 604659 Human

SwissProt: O42043 Human

SwissProt: O71037 Human

SwissProt: P10267 Human

SwissProt: P60507 Human

SwissProt: P60508 Human

SwissProt: P61550 Human

SwissProt: P61565 Human

SwissProt: P61566 Human

SwissProt: P61567 Human

SwissProt: P61570 Human

SwissProt: Q14264 Human

SwissProt: Q69384 Human

SwissProt: Q902F8 Human

SwissProt: Q902F9 Human

SwissProt: Q96L62 Human

SwissProt: Q9N2J8 Human

SwissProt: Q9N2J9 Human

SwissProt: Q9N2K0 Human

SwissProt: Q9NX77 Human

SwissProt: Q9UKH3 Human

SwissProt: Q9UQF0 Human

Unigene: 250693 Human

Unigene: 631996 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

合胞素(Syncytin)是一类由人俘获的逆转录病毒囊膜蛋白,与胎盘的形态发生中细胞滋养层到合胞滋养层的分化过程相关。Syncytin与人免疫缺陷病毒I型(HIV-1)囊膜蛋白(Env)在结构上具有相似的特点,二者可能具有相似的膜融合机制

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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